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Aromatic amino acid metabolism in brindled (Mo br) and viable-brindled (Mo vbr), two alleles at the mottled locus in the mouse

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Abstract

The central and peripheral levels of aromatic amino acids and monoamines have been studied in the X-linked mutants brindled (Mo br) and viable-brindled (Mo vbr) in the mouse. Significant differences were found in brain tyrosine (Mo br, Movbr) and tryptophan (Mo br) levels, which cannot be accounted for by observed changes in the systems of synthesis and degradation of these amino acids. Central norepinephrine is depressed to 30–45% (Mo br) and 55% (Mo vbr) normal level, but central dopamine and 5-hydroxy-tryptamine and peripheral norepinephrine are normal. These new data support the view that the effects of the mottled locus are not localized in the hair follicle, and the wider aspects of the mutant syndrome are discussed in relation to a possible neuroendocrine defect.

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Authors and Affiliations

  1. M.R.C. Experimental Genetics Unit, Department of Animal Genetics, University College, London, England

    D. M. Hunt & D. R. Johnson

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  1. D. M. Hunt
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  2. D. R. Johnson
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Hunt, D.M., Johnson, D.R. Aromatic amino acid metabolism in brindled (Mo br) and viable-brindled (Mo vbr), two alleles at the mottled locus in the mouse. Biochem Genet 6, 31–40 (1972). https://doi.org/10.1007/BF00485963

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  • DOI: https://doi.org/10.1007/BF00485963

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