Abstract
We report a new enzyme xylose dehydrogenase, the structural locus for which is on chromosome 7 of the mouse, closely linked to Tam-1. Three alleles have been detected in both laboratory strains and wild populations. Two of these determine proteins differing in electrophoretic mobility and the third is a “null.” This easily scored variation may prove useful both for gene mapping and in population genetics.
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Berry, R. J., and Peters, J. (1977). Heterogeneous heterozygosities in Mus musculus populations. Proc. R. Soc. Lond. B. 197485.
Berry, R. J., and Peters, J. (1981). Allozymic variation in house mouse populations. In Smith, M. H., and Joule, J. (eds)., Mammalian Population Genetics University of Georgia Press, Athens (in press).
Beutler, E., and Morrison, N. (1967). Localization and characteristics of hexose-6-phosphate dehydrogenase (glucose dehydrogenase). J. Biol. Chem. 2425289.
Chan, J. Y., Nwokoro, N. A., and Schachter, H. (1979). L-Fucose metabolism in mammals. J. Biol. Chem. 2547060.
Eicher, E. M., Taylor, B. A., Leighton, S. C., and Womack, J. E. (1980). A serum protein polymorphism determinant on chromosome 9 of Mus musculus. Mol. Gen. Genet. 177571.
Harris, H., and Hopkinson, D. A. (1976). Handbook of Enzyme Electrophoresis North-Holland Press, Amsterdam.
Hutton, J. J., and Coleman, D. L. (1969). Linkage analyses using biochemical variants in mice. II. Levulinate dehydratase and autosomal glucose 6-phosphate dehydrogenase. Biochem. Genet. 3517.
Petras, M. L., and Martin, J. E. (1969). Improved electrophoretic resolution of some Hb variants in Mus musculus. Biochem. Genet. 3303.
Ritter, H., Friedrichson, U., and Schmitt, J. (1974). Genetic polymorphism of hexokinase in primates. Humangenetik 22265.
Ruddle, F. H., Shows, T. B., and Roderick, T. H. (1968). Autosomal control of an electrophoretic variant of glucose-6-phosphate dehydrogenase in the mouse (Mus musculus). Genetics 58599.
Shull, K. H., and Miller, O. N. (1960). Formation in vivo of glycogen by certain intermediates of the lactate-propanediol pathway. J. Biol. Chem. 235551.
Skow, L. C. (1978). Genetic variation at a locus (TAM-1) for submaxillary gland protease in the mouse and its location on chromosome 7. Genetics 90713.
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This work was supported by the Medical Research Council.
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Newton, M.F., Nash, H.R., Peters, J. et al. Xylose dehydrogenase-1, a new gene on mouse chromosome 7. Biochem Genet 20, 733–745 (1982). https://doi.org/10.1007/BF00483970
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DOI: https://doi.org/10.1007/BF00483970