Summary
An attempt was made to assess the immunological importance of regional lymph node histology in relation to the survival of 107 patients with carcinoma of the larynx, operated on from 1973 to 1982 at the ENT-Clinic in Marburg. A total of 2765 sections of lymph nodes removed during neck dissections were examined microscopically to evaluate the morphological patterns of response. Microscopically, four distinct patterns were defined. Patients whose lymph nodes demonstrated immunological responses according to patterns I and II in the form of either expanded inner cortices or increased numbers of germinal centers had a greater 5-year survival rate than those patients whose lymph nodes showed an unstimulated pattern. Eight patients whose lymph nodes showed a depleted pattern, IV, did not survive more than 3 years. Morphological assessment of immunological activity in lymph nodes draining malignant tumors seems to be of value in predicting survival. The evaluation of the reaction pattern and difficulties in methodology, however, set definite limitations to our study.
Similar content being viewed by others
References
Anastassiades OT, Pryce PM (1966) Immunological significance of the morphological changes in lymph nodes drainig breast carcinoma. Br J Cancer 20:239–249
Bennett SH, Futrell JW, Roth JA, Hoye RC (1971) Prognostic significance of cytologic host response in cancer of the larynx and hypopharynx. Cancer 28:1255–1266
Berg JW (1956) Sinus histiocytosis — a fallacious measure of host resistance to cancer. Cancer 9:935–939
Berlinger NT (1976) Immunologic assessment of regional lymph node histology in relation to survival in head and neck carcinoma. Cancer 37:697–705
Berlinger NT, Tsakraklides V, Pollak K, Adams GL, Yang M, Good RA (1976) Prognostic significance of lymph node histology in patients with squamous cell carcinoma of larynx, pharynx and oral cavity. Laryngoscope 86:792–803
Black MM, Leis HP (1956) Sinus histiocytosis of lymph nodes in cancer. Surg Gynecol Obstet 102:599–603
Black MM, Kerpe S, Speer FD (1953) Lymph node structure in patients with cancer of the breast. Am J Pathol 29:505–521
Brynes RK (1983) Immunomorphologic changes in regional lymph nodes associated with cancer. Arch Pathol Lab Med 107:217–221
Burnet FM (1967) Immunological aspects of malignant disease. Lancet I:1171–1174
Catalona WJ, Chretien PB (1973) Abnormalities of quantitative dinitrochlorobenzene sensitization of cancer patients — correlation with tumor stage and histology. Cancer 31:353–356
Cottier H, Turk T, Sobin L (1973) A proposal for a standardized system of reporting human lymph node morphology in relation to immunologic function. J Clin Pathol 26:317–331
Cutler SJ, Black MM, Mark T, Harvel S (1969) Further investigations on prognostic factors in cancer of the female breast. Cancer 24:653–667
Di Re JJ, Lane N (1963) The relation of sinus histiocytosis in axillary lymph nodes to surgical curability of carcinoma of the breast. Am J Pathol 40:508–515
Edwards JA, Summer MR, Rowlands GF, Hurd CM (1971) Changes in lymphoreticular tissue during growth of murine adenocarcinoma. I. Histology and weight of lymph nodes, spleen and thymus. J Natl Cancer Inst 47:301–311
Ellis RJ, Wernicke G, Zabriskie JB, Goldman LI (1975) Immunologic competence of regional lymph nodes in patients with breast cancer. Cancer 35:655–659
Ferlito A, Polidoro F (1979) Biological and prognostic implications of the morphologic aspects of immune reaction in lymph nodes draining head and neck cancers. J Laryngol Otol 93:153–175
Fisher ER (1983) Types of tumor lymphoid response and sinus histiocytosis. Relationship to five-year, disease-free survival in patients with breast cancer. Arch Pathol Lab Med 107:222–227
Fisher B, Reidbord H, Fisher ER (1972) Studies concerning the regional lymph node in cancer. V. Histologic and ultrastructural findings in regional and non-regional lymph nodes. Lab Invest 28:128–133
Gilmore BB, Repola DA, Batsakis JG (1978) Carcinoma of the larynx: lymph node reaction patterns. Laryngoscope 88:1333–1338
Halsted W (1898) A clinical and histological study of certain adenocarcinomata of the breast. J Am Surg Assoc 15:114–181
Herr HW, Bean MA, Whitmore WF (1976) Prognostic significance of regional lymph node histology in cancer of the bladder. J Urol 115:264–267
Hunter R, Ferguson D, Coppleson LW (1975) Survival with mammary cancer related to the interaction of germinal center hyperplasia and sinus histiocytosis in axillary and internal mammary lymph nodes. Cancer 36:528–539
Kaufmann M, Wirth K, Zimmermann A, Luscieti P, Stjernswärd J (1977) Immunomorphological lymph node changes in patients with operable bronchogenic squamous cell carcinoma. Cancer 39:2371–2377
Kister SJ, Sommers SC, Haaigenesen CD, Friedell GH, Coley E, Varma A (1969) Nuclear grade and sinus histiocytosis in cancer of the breast. Cancer 23:570–575
Koenig UD (1978) Das Zervixkarzinom als tumorimmunologisches Modell. Teil I. Morphologische und seroepidemiologische Untersuchungen. Fortschr Med 33:1679–1683
McGavran MH, Bauer WC, Ogura JH (1961) The incidence of cervical lymph node metastasis from epidermoid carcinoma of the larynx and their relationship to certain characteristics of the primary tumour. Cancer 14:55–66
Meyer EM, Vollmer E, Rüller S, Krieg V, Vordemfelde A (1985) Histologisches Immunstaging beim kolorektalen Karzinom. In: Hermanek P (ed) Bedeutung des TNM-Systems für die klinische Onkolologie. Fortschritte in der Chirurgie 1. Symposium des DSK Erlangen 1985, pp 188–194
Moore RD, Chapnick R, Schoenberg MD (1960) Lymph nodes associated with carcinoma of the breast. Cancer 13:545–549
Patt DJ, Brynes RK, Vardiman JW, Coppleson WL (1975) Mesocolic lymph node histology is an important prognostic indicator for patients with carcinoma of the sigmoid colon: an immunomorphologic study. Cancer 35:1388–1397
Pihl E, Nairn RC, Rind AP, Muller HK, Hughes ESR (1976) Correlation of regional lymph node histology with in vitro antitumor cytotoxicity in colorectal carcinoma. Cancer Res 36:3665–3671
Pohris E (1982) Beziehung zwischen Überlebenszeit und histomorphologischen Reaktionen an regionären Lymphknoten bei Karzinomen des Kopfund Halsbereiches. Inaugural dissertation, Bonn
Remmele W (1984) Lymphknoten. In: Fischer R (ed) Pathologie 1. Springer, Berlin Heidelberg New York, pp 563–680
Silverberg S, Chitale A (1970) Sinus histiocytosis and mammary carcinoma. Study of 366 radical mastectomies and a historical review. Cancer 26:1177–1185
Syrjänen KJ (1979) Morphology of the lymph nodes draining renal adenocarcinoma in relation to immunologic function. Scand J Urol Nephrol 13:177–183
Tsakraklides V, Anastassiades OT, Kersey JH (1973) Prognostic significance of the regional lymph node histology in uterine cervical cancer. Cancer 31:860–868
Tsakraklides V, Olson P, Kersey JH, Good RA (1974) Prognostic significance of the regional lymph node histology in cancer of the breast. Cancer 34:1259–1267
Tsakraklides V, Tsakraklides E, Good RA (1975) An autopsy study of human axillary lymph node histology. Am J Pathol 78:7–22
Tsakraklides V, Vanebo H, Sternberg S, Stearns R, Good RA (1975) Prognostic evaluation of regional lymph node morphology in colorectal cancer. Am J Surg 129:174–180
Wartman WB (1959) Sinus cell hyperplasia of lymph nodes regional to adenocarcinoma of the breast and of the colon. Br J Cancer 13:389–397
Zechner G (1975) Morphologische Befunde zur Immunhistologie des Kehlkopfkrebses. Acta Otolaryngol 79:166–171
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pohris, E., Eichhorn, T., Glanz, H. et al. Immunohistological reaction patterns of cervical lymph nodes in patients with laryngeal carcinomas. Arch Otorhinolaryngol 244, 278–283 (1987). https://doi.org/10.1007/BF00468636
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00468636