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Correlation between Structural Transformations in Mesenteric Lymph Nodes and the Levels MicroRNA during Polychemotherapy of Breast Cancer

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Bulletin of Experimental Biology and Medicine Aims and scope

We studied interrelationships between the cytoarchitectonics of the mesenteric lymph node and the levels of microRNA-21, microRNA-221/222, and microRNA-429 in the lymph, blood serum, and breast tissues in female Wistar rats with chemically induced breast cancer. After polychemotherapy, significant correlations were found between miRNA-221 and the number of lymphoblasts in the germinal centers and between miRNA-222 and the number of lymphoblasts in the germinal centers and macrophages in the medullary cords of the mesenteric lymph nodes.

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Authors and Affiliations

  1. Research Institute of Clinical and Experimental Lymphology — Affiliated Branch of Federal Research Center Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

    A. V. Kabakov, O. V. Kazakov, A. F. Poveshchenko, A. P. Lykov, T. V. Raiter, V. I. Konenkov & A. Yu. Letyagin

  2. Novosibirsk State Pedagogical University, Novosibirsk, Russia

    A. F. Poveshchenko

  3. Research Institute of Molecular Biology and Biophysics — Structural Subdivision of the Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia

    D. N. Strunkin & L. F. Gulyaeva

Authors
  1. A. V. Kabakov
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  2. O. V. Kazakov
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  3. A. F. Poveshchenko
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  4. A. P. Lykov
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  5. T. V. Raiter
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  6. D. N. Strunkin
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  7. L. F. Gulyaeva
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  8. V. I. Konenkov
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  9. A. Yu. Letyagin
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Corresponding author

Correspondence to A. V. Kabakov.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 172, No. 10, pp. 483-487, October, 2021

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Kabakov, A.V., Kazakov, O.V., Poveshchenko, A.F. et al. Correlation between Structural Transformations in Mesenteric Lymph Nodes and the Levels MicroRNA during Polychemotherapy of Breast Cancer. Bull Exp Biol Med 172, 467–471 (2022). https://doi.org/10.1007/s10517-022-05415-4

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  • DOI: https://doi.org/10.1007/s10517-022-05415-4

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