Summary
Damages to inner ear function can be induced by improper application of ear drops. Which of the many substances combined in commercial otological preparations is mainly responsible, still remains a matter of controversy.
In guinea pigs a defined amount of different ear drops is applied to the round window over a constant time period and, at the same time, the inner ear function is determined by continuous recording of the compound action potentials and cochlear microphonics. In this way, the relative intratympanic ototoxicity of neomycin and tetracain concentration series can be compared with commercial aminoglycoside containing ear drops.
However, there are some ear drops which contain highly ototoxic substances, they show no significant differences of hearing loss to other.
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Renner, W., Matthias, R. & Handrock, M. Gefährden Ohrentropfen die Innenohrfunktion? Eine tierexperimentelle Untersuchung. Arch Otorhinolaryngol 235, 654–657 (1982). https://doi.org/10.1007/BF00459960
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DOI: https://doi.org/10.1007/BF00459960