Summary
Irritation of the postero-superior part of the tympanic membrane and canal wall skin with enbucrylate or gel foam in rabbits leads to cholesteatoma formation in 85% of the animals.
After elevating a tympano-meatal flap, the irritating substances were put in the middle ear of 25 rabbits. After 4 and 8 weeks a pronounced tissue reaction with cholesteatoma formation could be observed. Both the irritant substances and the trauma due to surgery are responsible for this marked reaction.
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Literatur
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Steinbach E (1981) Experimental studies on cholesteatoma formation. 2nd international conference on cholesteatoma and mastoid surgery, Tel Aviv
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Heumann, H., Steinbach, E. Zur Entstehung des Cholesteatoms als Folge einer experimentell verursachten Mittelohrentzündung. Arch Otorhinolaryngol 235, 577–579 (1982). https://doi.org/10.1007/BF00459924
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DOI: https://doi.org/10.1007/BF00459924