Abstract
Multiple gated blood pool (MUGA) and contrast ventriculographic studies were performed within 24 h in 80 patients, 20 with 120 normokinetic wall segments and 60 with wall motion abnormalities in 239 of 360 wall segments. Three methods of evaluation of the radionuclide ventriculograms were compared with the results of the biplane contrast ventriculography which served as a standard: (1) qualitative analysis of the cine mode, (2) analysis of parametric scans (amplitude and phase images) and the phase histogram obtained by Fourier analysis, (3) quantitative determination of regional ejection fraction. Normal values were obtained from 20 patients with normal wall motion in the contrast angiogram. The overall sensitivity for the detection of wall motion abnormalities of high degree was 96% for method 1, 95% for method 2, and 90% for method 3, for those of low degree 72% for method 1, 63% for method 2, and 75% for method 3. Combining methods 2 and 3 the sensitivity was increased to 99% for high grade and to 81% for low grade wall motion abnormalities. The two methods showed a complementary effect because of different sensitivities in dependence of the localization of the wall motion abnormality. Although a high efficiency for the evaluation of left ventricular function was provided by the qualitative analysis of the cine mode the combination of Fourier analysis and the determination of regional ejection fraction should be preferred. It increases the sensitivity for the detection of wall motion abnormalities. Moreover, it offers quantitative data which improve the reproducibility and decrease the observer variability.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
ADAC, Operator's manual, release 1981, 6.23.4, p 112 and 6.23.7, p 118
Adam WE, Sigel H, Geffers H, Kampmann H, Bitter F, Stauch M (1977) Analyse der regionalen Wandbewegung des linken Ventrikels bei koronarer Herzerkrankung durch ein nicht-invasives Verfahren. Z Kardiol 66:545
Adam WE, Tarkowska A, Bitter F, Strauch M, Geffers H (1979) Equilibrium (Gated) Radionuclide Ventriculography Cardiovasc Radiol 2:161
Bacharach SL, Green MV, Bonow RO, de Graaf CN, van Rijk PP, Johnston GS (1982) Cluster analysis of Fourier phase maps to detect left ventricular wall motion defects. In: Raynaud C (ed) Nuclear Medicine and Biology. I., Pergamon Press, Oxford, p 42
Berman DS, Maddahi J, Garcia EV, Freeman MR, Shah PK (1981) Assessment of left and right ventricular function with multiple gated equilibrium cardiac blood pool scintigraphy. In: Berman DS, Mason DT (eds) Clinical Nuclear Cardiology. Grune & Stratton, New York, p 224
Brady TJ, Thrall JH, Keyes JW, Brymer JF, Walton JA, Pitt B (1980) Segmental wall-motion analysis in the right anterior oblique projection: Comparison of exercise equilibrium radionuclide ventriculography and exercise contrast ventriculography. J Nucl Med 21:617
Büll U, Kleinhans E, Cyran J, Strauer BE (1980) Die Erfassung der Funktion des linken Ventrikels mit der Einkristall-Gammakamera im Rahmen der ersten Radionuklidpassage. Herz 5:133
Cardot JC, Berthout P, Verdenet J, Bidet A, Faivre R, Bassand JP, Bidet R, Maurat JP (1982) Temporal Fourier analysis applied to equilibrium radionuclide cineangiography. Importance in the study of global and regional left ventricular wall motion. Eur J Nucl Med 7:353
Chaitman BR, DeMots H, Bristow JD, Rösch J, Rahimtoola SH (1975) Objective and subjective analysis of left ventricular angiograms. Circulation 52:420
Cohn PF, Gorlin R, Adams DF, Chahine RA, Vokonas PS, Herman MV (1974) Comparison of biplane and single plane left ventriculograms in patients with coronary artery disease. Am J Cardiol 33:1
Gelberg HJ, Brundage BH, Glantz S, Parmley WW (1979) Quantitative left ventricular wall motion analysis: A comparison of area, chord and radial methods. Circulation 59:991
Karsch KR, Schicha H, Rentrop P, Blanke H, Kreuzer H, Emrich D (1980) Qualitative and semiquantitative Analyse der lokalen Wandfunktion mittels der Gated-blood-pool-Methode im Vergleich zur Cineventrikulographie. Z Kardiol 69:334
Links JM, Douglass KH, Wagner Jr HN (1980) Patterns of ventricular emptying by Fourier analysis of gated blood pool studies. J Nucl Med 21:978
Maddox DE, Holman BL, Wynne J, Idoine J, Parker JA, Uren R, Neill JM, Cohn PF (1978) Ejection fraction image: A noninvasive index of regional left ventricular wall motion. Am J Cardiol 41:1230
Maddox DE, Wynne J, Uren R, Parker JA, Idoine J, Siegel LC, Neill JM, Cohn PF, Holman BL (1979) Regional ejection fraction: A quantitative radionuclide index of regional left ventricular performance. Circulation 59:1001
Myers RW, Bails RP, Reed VR, Price JM, Drasin E, Hill JD, Saphir JR (1980) Angiocardiography with the seven pinhole collimator (SPC) — evaluation of methodology and accuracy in assessing global and regional left ventricular (LV) function. Clin Nucl Med 5:S55
Schad N, Nickel O (1979) Assessment of ventricular function with first-pass angiocardiography. In: Holman BL, Abrams HL, Zeitler E (eds) Cardiac nuclear medicine. Springer, Berlin, p 9
Sigel H, Nechwatal W, Stauch M (1981) Zur Frage der Reproduzierbarkeit von Parametern der quantitativen globalen and regionalen Lävangiografie im intra- und interindividuellen Observer-Vergleich. Z Kardiol 70:742
Standke R, Hör G, Maul F-D (1983) Fully automated sectorial equilibrium radionuclide ventriculography. Eur J Nucl Med 8:77
Tzivoni D, Diamond G, Pichler M, Stankus K, Vas R, Forrester J (1979) Analysis of regional ischemic left ventricular dysfunction by quantitative cineangiography. Circulation 60:1278
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Neumann, P., Schicha, H., Tebbe, U. et al. Analysis of left ventricular regional motility: A comparison of different methods. Eur J Nucl Med 9, 205–208 (1984). https://doi.org/10.1007/BF00448540
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00448540