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Is TOMPOOL (gated blood-pool SPECT processing software) accurate to diagnose right and left ventricular dysfunction in a clinical setting?

  • Original Article
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Journal of Nuclear Cardiology Aims and scope

Abstract

Background

The assessment of right ventricular function is crucial for management of heart disease. TOMPOOL is a software that processes data acquired with Tomographic Equilibrium Radionuclide Ventriculography. In this report, TOMPOOL’s diagnostic accuracy and inter-observer reproducibility were assessed in a cohort of patients with various etiologies of ventricular dysfunction.

Methods and Results

End-diastolic volume (EDV), ejection fraction (EF), and cardiac output (CO) were calculated for the right ventricle (RV) and the left ventricle (LV) using TOMPOOL in 99 consecutive patients. Thirty-five patients underwent cardiac magnetic resonance imaging (CMR) considered as the reference-standard to measure EDV and EF; the Spearman’s rho correlation coefficients were r = 0.73/0.80 and 0.67/0.73 for right/left EF and EDV, respectively. Twenty-one patients had thermodilution measurements of right CO (reference-standard), the correlation was r = 0.57. The best cut-off points (sensitivity/specificity) in order to diagnose a ventricular dysfunction or enlargement were 46% for RVEF (67%/89%), 62% for LVEF (100%/90%), 94 mL for RVEDV (77%/73%), and 84 mL for LVEDV (100%/91%). The areas under the ROC curve were, respectively, 0.79, 0.91, 0.83, and 0.99. Inter-observer reproducibility was r = 0.81/0.94, 0.77/0.90, and 0.78/0.75 for Right/Left EF, EDV, and CO, respectively.

Conclusion

TOMPOOL is accurate: measurements of EDV, EF, and CO are reproducible and correlate with CMR and thermodilution. However, thresholds must be adjusted.

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Acknowledgments

Authors thank the staff of the departments of nuclear medicine and radiology of Rangueil for their technical support.

Conflict of interest

There is no conflict of interest to declare.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Toulouse University Hospital, 1, Avenue Jean Poulhès TSA 50032, 31059, Toulouse Cedex 9, France

    Laurent Dercle MD, Pierre Pascal MD, Olivier Lairez MD, PhD, Delphine Bastié MD & Isabelle Berry MD, PhD

  2. Department of Radiology, Toulouse University Hospital, Toulouse, France

    Thomas Giraudmaillet MD, Marie-Agnès Marachet MD & Hervé Rousseau MD, PhD

  3. Department of Cardiology, University Hospital of Rangueil, Toulouse, France

    Olivier Lairez MD, PhD & Delphine Bastié MD

  4. Cardiac Imaging Center, Toulouse University Hospital, Toulouse, France

    Laurent Dercle MD, Olivier Lairez MD, PhD, Hervé Rousseau MD, PhD, Delphine Bastié MD & Isabelle Berry MD, PhD

  5. Medical School of Rangueil, University Paul Sabatier, Toulouse, France

    Olivier Lairez MD, PhD, Hervé Rousseau MD, PhD & Isabelle Berry MD, PhD

  6. Medical School of Purpan, University Paul Sabatier, Toulouse, France

    Olivier Lairez MD, PhD

  7. Department of Medical Biophysics and Nuclear Medicine, Hebrew University Hadassah Medical Center, Jerusalem, Israel

    Roland Chisin MD

  8. Department of Biostatistics, Institut Claudius Regaud, 20-24 rue du pont Saint Pierre, 31052, Toulouse, France

    Monia Ouali PhD

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  1. Laurent Dercle MD
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  2. Thomas Giraudmaillet MD
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  3. Pierre Pascal MD
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  10. Isabelle Berry MD, PhD
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Correspondence to Laurent Dercle MD.

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Dercle, L., Giraudmaillet, T., Pascal, P. et al. Is TOMPOOL (gated blood-pool SPECT processing software) accurate to diagnose right and left ventricular dysfunction in a clinical setting?. J. Nucl. Cardiol. 21, 1011–1022 (2014). https://doi.org/10.1007/s12350-014-9915-3

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  • DOI: https://doi.org/10.1007/s12350-014-9915-3

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