Abstract
In a search for Coxsackie B virus-induced, insulin-dependent diabetes mellitus (IDDM) we examined sera from 166 selected patients (age 1–17 years) with recent onset of IDDM for specific neutralizing antibodies. All 166 patients investigated had a clinical history of recent infectious illness. Eighty per cent of the patients had antibodies against at least one Coxsackie B virus type. But even among the children studied with antibody titers higher than 256 only in about 44% could a recent Coxsackie B virus infection be serologically demonstrated by determining specific neutralizing IgM antibodies. This result again strengthens the notion that IDDM includes several different etiologic groups, among others possibly Coxsackie B virus infections.
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References
Ahmad N, Abraham AA (1982) Pancreatic isleitis with Coxsackie virus B5 infection. Hum Pathol 13:661–662
Champsaur HF, Bottazzo GF, Bertrams J, Assan R, Bach Ch (1982) Virologic, immunologic, and genetic factors in insulin-dependent diabetes mellitus. J Pediatr 100:15–20
Craighead JE (1968) Diabetes mellitus: induction in mice by encephalomyocarditis virus. Science 162:913–914
Di Pietro C, Del Guercio MJ, Paolino GP, Barbi M, Ferrante P, Chiumello G (1979) Type I diabetes and Coxsackie virus infection. Helv Paediatr Acta 34:557–561
Gamble DR, Kinsley ML, Fitzgerald MG, Bolton R, Taylor KW (1969) Viral antibodies in diabetes mellitus. Br Med J 3:627–630
Mertens Th, Hager H, Eggers HJ (1982) Epidemiology of an outbreak in a maternity unit of infections with an antigenic variant of echovirus 11. J Med Virol 9:81–91
Nelson PG, Pyke DA, Gamble DR (1975) Viruses and the aetiology of diabetes: a study in identical twins. Br Med J 4:249–251
Rayfield EJ, Seto Y (1978) Viruses and the pathogenesis of diabetes mellitus. Diabetes 27:1126–1142
Sakurami T, Nabeya N, Nagaoka K, Matsumori A, Kuno S, Honda A (1982) Antibodies to Coxsackie B viruses and HLA in Japanese with juvenile-onset type I (insulin-dependent) diabetes mellitus. Diabetologia 22:375–377
Yoon JW, Austin M, Onodera T, Notkins AL (1979) Virus-induced diabetes mellitus: isolation of a virus from the pancreas of a child with diabetic ketoacidosis. N Engl J Med 300:1173–1179
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Mertens, T., Grüneklee, D. & Eggers, H.J. Neutralizing antibodies against Coxsackie B viruses in patients with recent onset of type I diabetes. Eur J Pediatr 140, 293–294 (1983). https://doi.org/10.1007/BF00442666
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DOI: https://doi.org/10.1007/BF00442666