Abstract
The aim of the study was to determine the role of the neostriatum in the syndromes produced by some drugs which affect monoaminergic transmission. Thirty days after bilateral destruction of the neostriatum, and in some cases the pallidum, rats were studied while under the action of reserpine, apomorphine or amphetamine. Under reserpine, intact rats developed rigidity, in operated animals rigidity was absent; otherwise the syndrome was the same in the two groups. Apomorphine and amphetamine produced sniffing and gnawing in operated as well as unoperated animals. In both groups haloperidol blocked the stereotyped behavior. Thus, of the symptoms produced by the examined drugs, only rigidity depends on an intact neostriatum.
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This research was supported by Grant MH 04726 from the NIMH, U.S. Public Health Service, awarded to J. M. Warren. CIBA generously supplied reserpine and McNeil haloperidol. Apomorphine and amphetamine were USP standard commercial products. The data were presented at the Second Scandinavian Meeting in Psychological Psychology, Psychophysiology and Psychopharmacology, Uppsala 1971.
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Divac, I. Drug-induced syndromes in rats with large, chronic lesions in the corpus striatum. Psychopharmacologia 27, 171–178 (1972). https://doi.org/10.1007/BF00439376
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DOI: https://doi.org/10.1007/BF00439376