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Untersuchung der Pankreas- und Gallenfunktion bei Säuglingen und Kindern

II. Befunde bei Patienten mit Cöliakie, Mucoviscidose und exokriner Pankreasinsuffizienz

Investigation of pancreas and gallbladder function in children

II. Results in patients with celiac disease, cystic fibrosis of the pancreas and exocrine pancreas insufficiency

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Abstract

A secretin-pancreozymin test was used to study exocrine pancreas function in 10 children with celiac disease, 4 with cystic fibrosis of the pancreas, 4 who had had a subtotal small bowel resection, 6 with exocrine pancreas insufficiency and 33 healthy children. Simultaneously the bile acids were measured in the gastric juice. 5 of the patients with exocrine pancreas insufficiency with no incidence of mucoviscidosis also showed lowered levels of bile acids. Under the test conditions, the children with total atrophy of the villi showed elevated volumes of gastric juices and elevated amounts of bile acids. In 2 cases with mucoviscidosis normal values were detected for bile acids in spite of a lowered volume of gastric juices.

Zusammenfassung

Bei 10 Kindern mit Cöliakie, 4 mit cystischer Pankreasfibrose, 4 Patienten nach einer subtotalen Dünndarmresektion, 6 Kindern mit exokriner Pankreasinsuffizienz und 33 pankreasgesunden Säuglingen und Kindern wurde die exokrine Pankreasfunktion mit Hilfe des Sekretin-Pankreozymin-Tests untersucht und gleichzeitig die Gesamtmenge an Gallensäure im Darmsaft bestimmt. 5 der Patienten mit exokriner Pankreasinsuffizienz ohne Vorliegen einer Mucoviscidose zeigten eine Verminderung der Gallensäuren. Bei den Kindern mit totaler Zottenatrophie fanden sich erhöhte Werte an Sekretvolumen und Gallensäuren. In 2 Fällen mit Mucoviscidose waren die Gallensäurenwerte im Darmsaft normal, obwohl das Sekretvolumen stark vermindert war.

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Authors and Affiliations

  1. Universitäts-Kinderklinik Tübingen, Tübingen, Germany

    K. H. Niessen, P. Oßwald, G. Brügmann, F. Hartmann, E. Droste & K. Schmidt

Authors
  1. K. H. Niessen
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  2. P. Oßwald
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  3. G. Brügmann
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  4. F. Hartmann
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  5. E. Droste
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  6. K. Schmidt
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Additional information

Auszugsweise auf der 70. Tagung der Deutschen Gesellschaft für Kinderheilkunde in Nürnberg am 17. 9. 1973 vorgetragen.

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Niessen, K.H., Oßwald, P., Brügmann, G. et al. Untersuchung der Pankreas- und Gallenfunktion bei Säuglingen und Kindern. Z. Kinder-Heilk. 116, 291–304 (1974). https://doi.org/10.1007/BF00436954

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  • DOI: https://doi.org/10.1007/BF00436954

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