Abstract
Preincubation of lymphocytes with des-Tyr1-γ-endorphin (DTγE) inhibits the reaction between some HLA alloantisera and their corresponding antigens. One HLA-A2-specific antiserum was found which could detect a subtype of the HLA-A2 antigen on DTγE-treated lymphocytes from some donors. Comparison with the HLA-A2 subtypes as defined by a combination of cytotoxic T lymphocyte typing and biochemistry showed a complete correlation with the previously described HLA-A2.3 subtype.
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Biddison, W. E., Kostyu, D. D, Strominger, J. L., and Krangel, M. S.: Delineation of immunologically and biochemically distinct HLA-A2 antigens. J. Immunol. 129: 730–734, 1982
Breuning, M. H., Lucas, C. J., Breur, B. S., Engelsma, M. Y., de Lange, G. G., Dekker, A. J., Biddison, W. E., and Ivanyi, P.: Subtypes of HLA-1327 detected by cytotoxic T lymphocytes and their role in self recognition. Hum. Immunol. 5: 259–268, 1982
Claas, F. H. J. and Van Rood, J. J.: The interaction between drugs and endogenous substances with HLA class I antigens. Prog. Allergy 36: 135–150, 1985
Claas, F., Castelli-Visser, R., Schreuder, I., and Van Rood, J.: Allo-antibodies to an antigenic determinant shared by HLA-A2 and B17. Tissue Antigens 19: 388–391, 1982a
Claas, F. H. J., Runia-van Nieuwkoop, R., Van de Berge, W., and Van Rood, J. J.: Interaction of penicillin with HLA-A and -B antigens. Hum. Immunol. 5: 83–90, 1982b
Claus, F. H. J., Castelli-Visser, R., De Jongh, B. M., Van Rood, J. J., Verhoeven, W. M. A., Van Ree, J. M., and De Wied, D.: Interaction between des-Tyr1-γ-endorphins and HLA class I molecules: Clinical relevance for the treatment of schizophrenia. In P. Medawar and T. Lehner (eds.): Major Histocompatibility System. The Gorer Symposium, pp. 106–113, Blackwell Scientific Publications, Oxford, England, 1985
De Jongh, B. M., Verhoeven, W. M. A., Van Ree, J. M., De Wied, D., and Van Rood, J. J.: HLA and the response to treatment with γ-type endorphins in schizophrenia. J. Immunogenet. 9: 381–388, 1982
Goulmy, E., Termijtelen, A., Bradley, B. A., and Van Rood, J. J.: HLA restriction of non-HLA-A, -B, -C and -D cell-mediated lympholysis (CML). Tissue Antigens 8: 317–326, 1976
Horai, S., Van der Poel, J. J., and Goulmy, E.: Differential recognition of the serologically defined HLA-A2 antigen by allogeneic cytotoxic T cells. I. Population studies. Immunogenetics 16: 135–142, 1982
Kato, S., Ivanyi, P., Lacko, E., Breur, B., du Bois, R., and Eysvoogel, V. P.: Identification of human CML targets. HLA-B locus (B12) antigen variants defined by CTLs generated between B-locus identical (B12) responder-stimulator pairs. J. Immunol. 128: 949–955, 1982
McMichael, A. J., Parham, P., Rust, N., and Brodsky, F.: A monoclonal antibody that recognizes an antigenic determinant shared by HLA-A2 and B17. Hum. Immunol. 1: 121–129, 1980
Mölders, H. H., Breuning, M. H., Ivanyi, P., and Ploegh, H. L.: Biochemical analysis of variant HLA-B27 antigens. Hum. Immunol. 6: 111–117, 1983
Russo, C., Ng, A.-K., Pellegrino, M.A., and Ferrone, S.: The monoclonal antibody CRII-351 discriminates HLA-A2 variants identified by T cells. Immunogenetics 18: 23–35, 1983
Van der Poel, J. J., Pool, J., Goulmy, E., and Van Rood, J. J.: Differential recognition of the serologically defined HLA-A2 antigen by allogeneic cytotoxic T cells. II. Definition of three HLA-A2 subtypes by CTLs. Immunogenetics 17: 599–608, 1983a
Van der Poel, J. J., Mölders, H., Thompson, A., and Ploegh, H. L.: Definition of four HLA-A2 subtypes by CML typing and biochemical analysis. Immunogenetics 17: 609–621, 1983b
Yang, S. Y., Morishima, Y., Collins, N. H., Alton, T., Pollack, M. S., Yunis, E. J., and Dupont, B.: Comparison of one-dimensional IEF patterns for serologically detectable HLA-A and B allotypes. Immunogenetics 19: 217–231, 1984
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Claas, F.H.J., van der Poel, J.J., Castelli-Visser, R. et al. Interaction between des-Tyr1-γ-endorphin and HLA class I molecules: Serological detection of an HLA-A2 subtype. Immunogenetics 22, 309–314 (1985). https://doi.org/10.1007/BF00430914
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DOI: https://doi.org/10.1007/BF00430914