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Effects of β-Endorphin on Functional Activity of Mouse Splenocytes under Conditions of In Vivo Blockade of μ,δ-Opioid Receptors

  • Microbiology and Immunology
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Bulletin of Experimental Biology and Medicine Aims and scope

Blockade of δ-receptors with naltrindole under conditions of systemic immunization abolished the stimulatory effect of β-endorphin (0.0005 μg/kg) on the counts of antibody-producing cells and the titer of antierythrocyte antibodies. Injection of β-endorphin to mice led to stimulation of concanavalin A-induced proliferative activity of splenocytes and IL-4 secretion by the naloxone-dependent mechanism. The peptide did not modify the production of IL-2 and IFN-γ.

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Authors and Affiliations

  1. Institute of Ecology and Genetics of Microorganisms, Ural Division of the Russian Academy of Sciences, Perm, Russia

    S. V. Gein & T. A. Baeva

  2. Perm State University, Perm, Russia

    S. V. Gein & V. O. Nebogatikov

Authors
  1. S. V. Gein
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  2. T. A. Baeva
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  3. V. O. Nebogatikov
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Correspondence to S. V. Gein.

Additional information

Translated from Byulleten’ Eksperimental’noi Biologii i Meditsiny, Vol. 158, No. 9, pp. 344-348, September, 2014

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Gein, S.V., Baeva, T.A. & Nebogatikov, V.O. Effects of β-Endorphin on Functional Activity of Mouse Splenocytes under Conditions of In Vivo Blockade of μ,δ-Opioid Receptors. Bull Exp Biol Med 158, 356–360 (2015). https://doi.org/10.1007/s10517-015-2761-8

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  • DOI: https://doi.org/10.1007/s10517-015-2761-8

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