Summary
Antisera against total keratin extracts of human callus have been used to identify keratins in lung tumours of different histological type. Forty-three were classified by the WHO scheme. Keratin immunoreactive cells were identified in all 8 epidermoid carcinomas; 6 out of 12 large cell carcinomas; 2 out of 6 adenocarcinomas; 2 out of 15 small cell carcinomas and in the only muco-epidermoid carcinoma. These cases demonstrate the heterogeneity of phenotypic expression in lung tumours not recognisable without the use of immunohistochemical techniques.
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Gusterson, B., Mitchell, D., Warburton, M. et al. Immunohistochemical localisation of keratin in human lung tumours. Virchows Arch. A Path. Anat. and Histol. 394, 269–277 (1982). https://doi.org/10.1007/BF00430670
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DOI: https://doi.org/10.1007/BF00430670