Abstract
A structural locus (C-6) for the sixth component of complement in mice is assigned to chromosome 15. Three-point linkage analysis indicated that the order of loci is C-6, Gpt-1, Gdc-1, and that the map distances are 25.9±4.9 between C-6 and Gpt-1, and 36.4±5.5 between C-6 and Gdc-1. Since Gdc-1 is more distal than Gpt-1, and C-6 is 26 cM away from Gpt-1, it is estimated that the C-6 is proximal to the centromere. In addition, a new C6 form found in AKR mice is described. We propose the designation C6B for it and C-6 b for the allele encoding C6B.
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Abbreviations
- IEF:
-
isoelectric focusing
- GPT:
-
glutamic-pyruvic transaminase
- GDC:
-
L-glycerol 3-phosphate dehydrogenase
- cM:
-
centimorgan
References
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Hayakawa, Ji., Nikaido, H. & Koizumi, T. Assignment of the gene locus for the sixth component (C6) of complement in mice to chromosome 15. Immunogenetics 22, 637–642 (1985). https://doi.org/10.1007/BF00430312
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DOI: https://doi.org/10.1007/BF00430312