Summary
A comparative trial of two antidepressant drugs on 100 out-patients extending over six weeks is described. Overall response to the drugs was not significantly different, and the overall favourable responses may be related to the inclusion of only mild and moderate cases. The occurence of some age and sex differences in response to treatment while probably spurious suggest a hypothesis that women over 40 with depression will respond better to imipramine while men under 40 with depression will show greater improvement on phenelzine. Both drugs appear to have clinical value in the treatment of an assortive group of mild and moderately depressed out-patients.
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References
Leitch, A., and S. P. Seager: Psychopharmacologia (Berl.) 4, 72–77 (1963).
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Imlah, N.W., Fahy, P.T.P. & Harrington, J.A. A comparison of two antidepressant drugs. Psychopharmacologia 6, 472–474 (1964). https://doi.org/10.1007/BF00429573
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DOI: https://doi.org/10.1007/BF00429573