Abstract
Rats were given dl-amphetamine 16 mg/kg twice daily for 15 days. Complete tolerance to the anorexigenic effect of amphetamine developed from day 7–11. A single injection of 16 mg/kg amphetamine was given to the amphetamine pretreated rats and to saline pretreated controls at different time-points after withdrawal, and their food intakes were compared. Signs of tolerance were present at 16 but not 20 days after withdrawal.
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Götestam, K.G., Lewander, T. The duration of tolerance to the anorexigenic effect of amphetamine in rats. Psychopharmacologia 42, 41–45 (1975). https://doi.org/10.1007/BF00428823
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DOI: https://doi.org/10.1007/BF00428823