Abstract
Salsolinol, a compound putatively formed following alcohol ingestion, differentially decreased the activity of lines of mice after 18 generations of genetic selection for alcohol sensitivity. Low doses of salsolinol produced significantly lower activity levels in the alcohol-sensitive long-sleep (LS) line than in the alcohol-insensitive short-sleep (SS) line. A hypnotic dose of salsolinol induced significantly longer sleep-times in the LS line than in the SS line. Results are interpreted as supporting the hypothesis that salsolinol-like substances may mediate some of the effects of alcohol on the central nervous system.
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References
Cohen, G.: A role for tetrahydroisoquinoline alkaloids as false adrenergic neurotransmitters in alcoholism. In: Alcohol intoxication and withdrawal, M. Gross, ed., pp. 33–34. New York: Plenum Press 1973
Cohen, G., Collins, M. A.: Alkaloids from catecholamines in adrenal tissue: Possible role in alcoholism. Science 167, 1749–1751 (1970)
Collins, M. A.: Tetrahydroisoquinoline alkaloids from condensation of alcohol metabolites with norepinephrine: preparative synthesis and potential analysis in nervous tissue by gas chromatography. Ann. N.Y. Acad. Sci. 215, 92–97 (1973)
Collins, M. A., Bigdeli, M. G.: Tetrahydroisoquinolines in vivo. I. Rat brain formation of salsolinol, a condensation product of dopamine and acetaldehyde, under certain conditions during ethanol intoxication. Life Sci. 16, 585–602 (1975)
Davis, V. E.: Alcohol and aberrant metabolism of biogenic amines. In: Biological aspects of alcohol, M. K. Roach, W. M. McIssac, P. J. Creaven, eds., pp. 293–312. Austin: University of Texas Press 1971
Davis, V. E.: Neuroamine-derived alkaloids: Possible common denominator in alcoholism and related drug dependencies. Ann. N.Y. Acad. Sci. 215, 111–115 (1973)
Davis, V. E., Walsh, M. J.: Alcohol, amines, and alkaloids: A possible biochemical basis for alcohol addiction. Science 167, 1005–1007 (1970)
Fuller, J. L.: Variation in effects of chlorpromazine in three strains of mice. Psychopharmacologia (Berl.) 8, 408–414 (1966)
Greenberg, R. S., Cohen, G.: Tetrahydroisoquinoline alkaloids: Stimulated secretion from the adrenal medulla. J. Pharmacol. exp. Ther. 184, 119–128 (1973)
Heikkila, R., Cohen, G., Dembiec, D.: Tetrahydroisoquinoline alkaloids: Uptake by rat brain homogenates and inhibition of catecholamine uptake. J. Pharmacol. exp. Ther. 179, 250–258 (1971)
Heston, W. D. W., Erwin, V. G., Anderson, S. M., Robbins, H.: A comparison of the effects of alcohol on mice selectively bred for differences in ethanol sleeptime. Life Sci. 14, 365–370 (1974)
Hollander, M., Wolfe, D. A. (eds.): Nonparametric statistical methods, p. 68. New York: Wiley 1973
Locke, S., Cohen, G., Dembiec, D.: Uptake and accumulation of H3-6,7-dihydroxytetrahydroisoquinoline by peripheral sympathetic nerves in vivo. J. Pharmacol. exp. Ther. 187, 56–67 (1973)
McClearn, G. E., Kakihana, R.: Selective breeding for ethanol sensitivity in mice. Behav. Genet. 3, 409 (1973)
Schanberg, S. M., Schildkraut, J. J., Kopin, I. J.: The effects of pentobarbital on the fate of intracisternally administered NE-H3. J. Pharmacol. exp. Ther. 157, 311–318 (1967)
Simpson, L. L.: An analysis of the sympathomimetic activity of 6,7-dihydroxy-1,2,3,4-tetrahydroisoquinoline (TIQ). J. Pharmacol. exp. Ther. 192, 365–371 (1975)
Tennyson, V. M., Cohen, G., Mytilineou, C., Heikkila, R.: 6,7-Dihydroxytetrahydroisoquinoline: electron microscopic evidence for uptake into amine-binding vesicles in sympathetic nerves of rat iris and pineal gland. Brain Res 51, 161–169 (1973)
Walsh, M. J.: Biogenesis of biologically active alkaloids from amines by alcohol and acetaldehyde. Ann. N.Y. Acad. Sci. 215, 98–110 (1973)
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Church, A.C., Fuller, J.L. & Dudek, B.C. Salsolinol differentially affects mice selected for sensitivity to alcohol. Psychopharmacology 47, 49–52 (1976). https://doi.org/10.1007/BF00428700
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DOI: https://doi.org/10.1007/BF00428700