Skip to main content
SpringerLink
Log in

Interaction between prior experience and the effects of chlorpromazine on exploration in the rat

  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Abstract

4 mg/kg chlorpromazine increased the latency to start exploring a new environment, and decreased the time spent exploring it and novel objects in it A prior, undrugged experience of the apparatus reduced this drug effect, whereas a prior, drugged experience had little effect on later exploration under saline conditions. Rats placed undrugged in the apparatus on two trials showed significant habituation of exploration, but rats given both trials when drugged did not.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  • Berlyne, D. E.: Conflict arousal and curiosity. New York: McGraw-Hill 1960

    Google Scholar 

  • Estes, W. K.: Stimulus-response theory of drive. Neb. Symp. Motivation, pp. 35–69 (1958)

  • File, S. E.: Potentiation of the effects of chlorpromazine on exploration in the rat by a prior experience of the drug. Psychopharmacologia (Berl.) 29, 357–363 (1973a)

    Google Scholar 

  • File, S. E.: Effect of chlorpromazine on exploration and habituation in the rat. To be published in Brit. J. Pharmacol. exp. Ther. (1973b)

  • File, S. E.: Changes in orienting and habituation in the rat following administration of chlorpromazine. To be published in Quart. J. exp. Psychol. (1973c)

  • File, S. E., Day, S.: Effects of time of day and food deprivation on exploratory activity in the rat. Anim. Behav. 20, 758–762 (1972)

    Google Scholar 

  • Hughes, R.: Chlordiazepoxide modified exploration in rats. Psychopharmacologia (Berl.) 24, 462–469 (1972)

    Google Scholar 

  • Kumar, R.: Effects of chlordiazepoxide and chlorpromazine on fear and exploratory behaviour in rats. Psychopharmacologia (Berl.) 19, 297–312 (1971)

    Google Scholar 

  • Kumar, R., Stolerman, I. P., Steinberg, H.: Psychopharmacology. Ann. Rev. Psychol. 21, 595–628 (1970)

    Google Scholar 

  • Marriott, A. S., Spencer, P. S.: Effects of centrally acting drugs on exploratory behaviour in rats. Brit. J. Pharmacol. Chemother. 25, 432–441 (1965)

    Google Scholar 

  • Rushton, R., Steinberg, H., Tinson, C.: Effects of a single experience on subsequent reactions to drugs. Brit. J. Pharmacol. Chemother. 20, 99–105 (1963)

    Google Scholar 

  • Rushton, R., Steinberg, H., Tomkiewicz, M.: Equivalence and persistence of the effects of psychoactive drugs and past experience. Nature (Lond.) 220, 885–888 (1968)

    Google Scholar 

  • Shillito, E. E.: The effects of chlorpromazine and thioridazine on the exploration of a Y-maze by rats. Brit. J. Pharmacol. Chemother. 30, 258–264 (1967)

    Google Scholar 

  • Steinberg, H., Rushton, R., Tinson, C.: Modification of the effects of an amphetamine-barbiturate mixture by the past experience of rats. Nature (Lond.) 192, 533–535 (1961).

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Psychology, City of London Polytechnic, London, England

    Sandra E. File

Authors
  1. Sandra E. File
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

File, S.E. Interaction between prior experience and the effects of chlorpromazine on exploration in the rat. Psychopharmacologia 32, 193–200 (1973). https://doi.org/10.1007/BF00428690

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00428690

Key Words

Search

Navigation