Abstract
The quantitative electroencephalogram (EEG) and plasma concentration of the antidepressant paroxetine were monitored in five normal volunteers after a single oral dose of 70 mg paroxetine and placebo. Peak plasma concentration occurred 4–6 h post-dose. Placebo had little effect on the EEG but the effects of paroxetine were statistically significant at 6 h post-dose. The EEG changes after treatment consisted of a decrease in delta and theta activity (< 8 Hz) and increase in beta activity (>12 Hz). These changes were still evident 72 h after treatment. The EEG profile obtained with 70 mg paroxetine is similar to that reported for other antidepressant 5-HT uptake inhibitors, but dissimilar to the classical, sedative antidepressants.
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Buss Lassen J (1978a) Potent and long-lasting potentiating of two 5-hydroxytryptophan-induced effects in mice by three selective 5-HT uptake inhibitors. Eur J Pharmacol 47:351–358
Buss Lassen J (1978b) Influence of the new 5-HT uptake inhibitor paroxetine on hypermotility in rats produced by p-chloroamphetamine (PCA) and 4,α-dimethyl-m-tyramine (H77/77). Psychopharmacology 57:151–153
Fink M, Irwin P, Gastpar M, Deridder JJ (1977) EEG, blood level, and behavioral effects of the antidepressant mianserin (ORG GB94). Psychopharmacology 54:249–254
Heel RC, Morley PA, Brogden RN, Carmine AA, Speight TM, Avery GS (1982) Zimelidine: a review of its pharmacological properties and therapeutic efficacy in depressive illness. Drugs 24:169–206
Irwin P (1982) Spectral Difference Index: a single EEG measure of drug effect. Electroencephalogr Clin Neurophysiol 54: 342–346
Itil TM, Polvan N, Hsu W (1972) Clinical and EEG effects of GB94, a “tetracyclic” antidepressant. (EEG model in discovery of a new psychotropic drug.) Curr Ther Res 14:394–413
Itil TM (1974) Quantitative pharmaco-electroencephalography. In: Itil TM (ed) Psychotropic drugs and the human EEG. Karger, Basel, pp 43–75
Itil TM, Bhattachyara A, Polvan N, Huque M, Menom GN (1977) Fluvoxamine (Du-23,000), a new antidepressant. Quantitative pharmacoelectroencephalography and pilot clinical trials. Prog Neuro-Psychopharmacol 1:309–322
Klok CJ, Brouwer GJ, van Praag HM, Doogan D (1981) Fluvoxamine and clomipramine in depressed patients. Acta Psychiatr Scand 64:1–11
Lund J, Lomholt B, Fabricius J, Christensen JA, Bechgaard E (1979) Paroxetine: pharmacokinetics, tolerance and depletion of blood 5-HT in man. Acta Pharmacol Toxicol 44:289–295
Petersen EN, Olsson SO, Squires RF (1977) Effects of 5-HT uptake inhibition on the pressor response to 5-HT in the pithed rat. The significance of 5-HT blocking property. Eur J Pharmacol 43:209–215
Petersen EN, Bechgaard E, Sortwell RJ, Wetterberg L (1978) Potent depletion of 5-HT from monkey whole blood by a new 5-HT uptake inhibitor, paroxetine (FG7051). Eur J Pharmacol 52:115–119
Saito M, Kita S, Kagono Y (1980) Drug induced changes and the orientations of clinical effects — zimelidine and sulpiride. Presentation to Conference EEG in Drug Research, Berlin, June 1980
Saletu B (1982) Pharmaco-EEG profiles of typical and atypical antidepressants. In: Costa E, Racagni G (eds) Typical and atypical antidepressants: Clinical practice. Raven Press, New York, pp 257–268
Saletu B, Grunberger J, Rajna P (1983) Pharmaco-EEG profiles of antidepressants. Pharmacodynamic studies with fluvoxamine. Br J Clin Pharmacol 15:369–384
Schenk GK, Filler W, Rauft W, Zerbin D (1981) Double-blind comparisons of a selective serotonin uptake inhibitor, zimelidine, and placebo on quantified EEG parameters and psychological variables. In: Recent advances in the treatment of depression. Acta Psychiatr Scand 63 (Suppl):303–313
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McClelland, G.R., Raptopoulos, P. EEG and blood level of the potential antidepressant paroxetine after a single oral dose to normal volunteers. Psychopharmacology 83, 327–329 (1984). https://doi.org/10.1007/BF00428539
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DOI: https://doi.org/10.1007/BF00428539