Skip to main content
Log in

Behavioural effects of yohimbine administered intraventricularly in the rat

  • Published:
Psychopharmacologia Aims and scope Submit manuscript

Abstract

The influence of yohimbine injected into the lateral cerebral ventricle on the behaviour of white Wistar rats was investigated. Yohimbine in low doses (1–5 Μg) produced excitatory effects but in high doses (20–100 Μg) it induced central depression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Boissier, J. R.: Effects centraux de quelques substances adreno- et/ou sympatholytiques. II. Action sur la motilité spontanée et potentialisation du pentobarbital. Arch. int. Pharmacodyn. 169, 312–319 (1967)

    Google Scholar 

  • Boissier, J. R.: Effects centraux de quelques substances adreno- et/ou sympahtolytiques. III. Ptosis, catalepsie, antagonisme visa-vis de l'apomorphine et l'amphetamine. Arch. int. Pharmacodyn. 171, 68–80 (1968)

    Google Scholar 

  • Boissier, J. R., Simon, P., Guidicelli, J. F.: Effects centraux de quelques substances adreno- et/ou sympatholytiques. I.Action sur la temperature rectale. Arch. int. Pharmacodyn. 168, 180–187 (1967)

    Google Scholar 

  • Fonteney, M., Le Cornec, J., Zaczyńska, M., Debarle, M. C., Simon, P., Boissier, J. R.: Problémes posés per l'utilisation de trois tests de comportement du rat pour l'étude de medicaments psychotropes. J. Pharmacol. (Paris) 1, 243–254 (1970)

    Google Scholar 

  • Gershon, S., Lang, W. J.: A psychopharmacological study of some indole alcaloids. Arch. int. Pharmacodyn. 135, 31–56 (1962)

    Google Scholar 

  • Herman, Z. S.: The effects of noradrenaline on rat's behaviour. Psychopharmacologia (Berl.) 16, 369–374 (1970)

    Google Scholar 

  • Holmberg, G., Gershon, S., Beck, L. H.: Yohimbine as an automic test drug. Nature (Lond.) 193, 1313–1314 (1962)

    Google Scholar 

  • Kleinrok, Z., żebrowska-łupina, I.: Central action of phentolamine administered intraventricularly in the rat. Psychopharmacologia (Berl.) 20, 348–354 (1971)

    Google Scholar 

  • Lang, W. J., Gershon, S.: Effects of psychoactivity drugs on yohimbine induced responses in conscious dogs. Arch. int. Pharmacodyn. 142, 457–472 (1963)

    Google Scholar 

  • Maj, J., Grabowska, M., Mogilnicka, E.: The effect of L-DOPA on brain catecholamines and motility in rats. Psychopharmacologia (Berl.) 22, 162–171 (1971)

    Google Scholar 

  • Maj, J., Sowińska, H., Baran, L., Kapturkiewicz, Z.: The effect of clonidine on locomotor activity in mice. Life Sci. 11, 483–491 (1972)

    Google Scholar 

  • Papeshi, R., Sourkes, T. L., Youdium, M. B. H.: The effect of yohimbine on brain serotonin metabolism, motor behavior and body temperature of the rat. Europ. J. Pharmacol. 15, 318–326 (1971)

    Google Scholar 

  • Randrup, A., Munkvad, J., Udsen, P.: Adrenergic mechanisms and amphetamine induced abnormal behaviour. Acta pharmacol. (Kbh.) 20, 145–157 (1963)

    Google Scholar 

  • Sanghvi, I., Gershon, S.: Similarities between behavioral and pharmacological actions of yohimbine and 5-hydroxytryptophan in the conscious dog. Europ. J. Pharmacol. 11, 125–129 (1970)

    Google Scholar 

  • Scheel-Krüger, J., Randrup, A.: Stereotyped hyperactive behaviour produced by dopamine in the absence of noradrenaline. Life Sci. 6, 1389–1393 (1967)

    Google Scholar 

  • Ungerstedt, U., Butcher, L. L., Butcher, S. G., Anden, N. E., Fuxe, K.: Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat. Brain Res. 14, 461–471 (1969)

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

żebrowska-łupina, I., Kleinrok, Z. Behavioural effects of yohimbine administered intraventricularly in the rat. Psychopharmacologia 33, 267–275 (1973). https://doi.org/10.1007/BF00423061

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00423061

Key words

Navigation