Abstract
The influence of yohimbine injected into the lateral cerebral ventricle on the behaviour of white Wistar rats was investigated. Yohimbine in low doses (1–5 Μg) produced excitatory effects but in high doses (20–100 Μg) it induced central depression.
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Boissier, J. R.: Effects centraux de quelques substances adreno- et/ou sympatholytiques. II. Action sur la motilité spontanée et potentialisation du pentobarbital. Arch. int. Pharmacodyn. 169, 312–319 (1967)
Boissier, J. R.: Effects centraux de quelques substances adreno- et/ou sympahtolytiques. III. Ptosis, catalepsie, antagonisme visa-vis de l'apomorphine et l'amphetamine. Arch. int. Pharmacodyn. 171, 68–80 (1968)
Boissier, J. R., Simon, P., Guidicelli, J. F.: Effects centraux de quelques substances adreno- et/ou sympatholytiques. I.Action sur la temperature rectale. Arch. int. Pharmacodyn. 168, 180–187 (1967)
Fonteney, M., Le Cornec, J., Zaczyńska, M., Debarle, M. C., Simon, P., Boissier, J. R.: Problémes posés per l'utilisation de trois tests de comportement du rat pour l'étude de medicaments psychotropes. J. Pharmacol. (Paris) 1, 243–254 (1970)
Gershon, S., Lang, W. J.: A psychopharmacological study of some indole alcaloids. Arch. int. Pharmacodyn. 135, 31–56 (1962)
Herman, Z. S.: The effects of noradrenaline on rat's behaviour. Psychopharmacologia (Berl.) 16, 369–374 (1970)
Holmberg, G., Gershon, S., Beck, L. H.: Yohimbine as an automic test drug. Nature (Lond.) 193, 1313–1314 (1962)
Kleinrok, Z., żebrowska-łupina, I.: Central action of phentolamine administered intraventricularly in the rat. Psychopharmacologia (Berl.) 20, 348–354 (1971)
Lang, W. J., Gershon, S.: Effects of psychoactivity drugs on yohimbine induced responses in conscious dogs. Arch. int. Pharmacodyn. 142, 457–472 (1963)
Maj, J., Grabowska, M., Mogilnicka, E.: The effect of L-DOPA on brain catecholamines and motility in rats. Psychopharmacologia (Berl.) 22, 162–171 (1971)
Maj, J., Sowińska, H., Baran, L., Kapturkiewicz, Z.: The effect of clonidine on locomotor activity in mice. Life Sci. 11, 483–491 (1972)
Papeshi, R., Sourkes, T. L., Youdium, M. B. H.: The effect of yohimbine on brain serotonin metabolism, motor behavior and body temperature of the rat. Europ. J. Pharmacol. 15, 318–326 (1971)
Randrup, A., Munkvad, J., Udsen, P.: Adrenergic mechanisms and amphetamine induced abnormal behaviour. Acta pharmacol. (Kbh.) 20, 145–157 (1963)
Sanghvi, I., Gershon, S.: Similarities between behavioral and pharmacological actions of yohimbine and 5-hydroxytryptophan in the conscious dog. Europ. J. Pharmacol. 11, 125–129 (1970)
Scheel-Krüger, J., Randrup, A.: Stereotyped hyperactive behaviour produced by dopamine in the absence of noradrenaline. Life Sci. 6, 1389–1393 (1967)
Ungerstedt, U., Butcher, L. L., Butcher, S. G., Anden, N. E., Fuxe, K.: Direct chemical stimulation of dopaminergic mechanisms in the neostriatum of the rat. Brain Res. 14, 461–471 (1969)
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żebrowska-łupina, I., Kleinrok, Z. Behavioural effects of yohimbine administered intraventricularly in the rat. Psychopharmacologia 33, 267–275 (1973). https://doi.org/10.1007/BF00423061
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DOI: https://doi.org/10.1007/BF00423061