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Inhibitory Effects of Ethanol in the Neonatal Rat Hippocampus In Vivo

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Abstract

Ethanol-induced neuroapoptosis in the developing brain has been suggested to involve suppression of neuronal activity. However, ethanol acts as a potent stimulant of neuronal activity by increasing the frequency of depolarizing GABA dependent giant depolarizing potentials in the neonatal rat hippocampal slices in vitro. Here, we show that ethanol strongly inhibits, in a dose-dependent manner (1–6 g/kg), sharp waves and multiple unit activity in the hippocampus of neonatal (postnatal days P4–6) rats in vivo. Thus, the effects of ethanol on the developing hippocampal network activity cardinally differ in vitro (stimulation) and in vivo (inhibition).

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Acknowledgments

This work was supported by the Program of Competitive Growth of Kazan Federal University, the subsidy allocated to Kazan Federal University for the state assignment in the sphere of scientific activities and by INSERM (LIA).

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Authors and Affiliations

  1. Laboratory of Neurobiology, Kazan Federal University, 18 Kremlevskaya str., Kazan, 420008, Russia

    Kseniya Chernova, Gulshat Burkhanova, Andrey Zakharov, Roustem Khazipov & Guzel Sitdikova

  2. Department of Physiology, Kazan State Medical University, Kazan, 420012, Russia

    Andrey Zakharov

  3. INMED—INSERM U901, 163 avenue de Luminy, Marseille, 13273, France

    Roustem Khazipov

  4. Aix-Marseille University, Marseille, 13273, France

    Roustem Khazipov

Authors
  1. Kseniya Chernova
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  2. Gulshat Burkhanova
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  3. Andrey Zakharov
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  4. Roustem Khazipov
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  5. Guzel Sitdikova
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Corresponding author

Correspondence to Andrey Zakharov.

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Chernova, K., Burkhanova, G., Zakharov, A. et al. Inhibitory Effects of Ethanol in the Neonatal Rat Hippocampus In Vivo. BioNanoSci. 7, 159–161 (2017). https://doi.org/10.1007/s12668-016-0328-4

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  • DOI: https://doi.org/10.1007/s12668-016-0328-4

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