Abstract
α-Flupenthixol and α-flupenthixol decanoate were tested in mice against methylphenidate-induced stereotyped gnaw-compulsions. The effect of both α-flupenthixol, and α-flupenthixol decanoate disappeared 2 days after administration.
In addition, the influence of α-flupenthixol and α-flupenthixol decanoate on the apomorphine-induced behaviour in mice was followed over a period of 12 days. Under these conditions apomorphine-induced compulsive gnawing was seen on the days on which the methylphenidate antagonistic effect had subsided.
The apomorphine-induced compulsive gnawing seen in α-flupenthixol and α-flupenthixol decanoate pretreated animals could be antagonized by additional small doses of α-flupenthixol given 2 h before apomorphine. The interference of the neuroleptic drugs with dopaminergic receptors is discussed.
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References
Andén, N.-E., Rubinson, A., Fuxe, K., Hökfelt, T.: Evidence for dopamine receptor stimulation by apomorphine. J. Pharm. Pharmacol. 19, 627–629 (1967)
Fjalland, B., MØller Nielsen, I.: Enhancement of methylphenidate induced stereotypies by repeated administration of neuroleptics. Psychopharmacologia (Berl.) 34, 105–109 (1974)
Hall, P., Coleman, J.: Flupenthixol in the treatment of depressive states. Brit. J. Psychiat. 122, 120 (1973)
Itil, T. M., Saletu, B., Hsu, W., Kiremitci, N., Keskiner, A.: Clinical and quantitative EEG changes at different dosage levels of fluphenazine treatment. Acta psychiat. scand. 47, 440–451 (1971)
Lodge Patch, I. C., Pitt, B. M., Yeo, Y. M.: The direct comparison of antidepressants: Imipramine and chlorprothixene. J. psychiat. Res. 5, 273–280 (1967)
MØller Nielsen, I., Fjalland, B., Pedersen, V., Nymark, M.: Pharmacology of neuroleptics given by repeated administration. Psychopharmacologia (Berl.) 34, 95–104 (1974)
Pedersen, V.: Potentiation of apomorphine effect (compulsive gnawing behaviour) in mice. Acta pharmacol. (Kbh.) 25, Suppl. 4, 63 (1967)
Pedersen, V.: Role of catecholamines in compulsive gnawing behaviour in mice. Brit. J. Pharmacol. 34, 219 P (1968)
Pedersen, V., Christensen, A. V.: Antagonism of methylphenidate-induced stereotyped gnawing in mice. Acta pharmacol. (Kbh.) 31, 488–496 (1972)
Pöldinger, W.: Ein Neurolepticum mit antidepressive Wirkung „Taractan” (Ro 4-0403). Praxis 49, 468–472 (1960)
Scheel-Krüger, J.: Comparative studies of various amphetamine analogues demonstrating different interactions with the metabolism of the cateoholamines in the brain. Europ. J. Pharmacol. 14, 47–59 (1971)
Sonne, L. M.: Behandling af depressive tilstande med flupenthixol. Nord. psykiat. T. 25, 454–463 (1971)
Ther, L., Schramm, H.: Apomorphin-synergismus (Zwangsnagen bei MÄusen) als Test zur Differenzierung psychotroper Substanzen. Arch. int. Pharmacodyn. 138, 302–310 (1962)
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Christensen, A.V., Nielsen, I.M. Influence of flupenthixol and flupenthixol-decanoate on methylphenidate and apomorphine-induced compulsive gnawing in mice. Psychopharmacologia 34, 119–126 (1974). https://doi.org/10.1007/BF00421936
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DOI: https://doi.org/10.1007/BF00421936