Abstract
The dose-response relationships for three stimulants have been explored. These drugs have been shown to differ in potency and, with successive doubling of doses, have been found to have dose-response curves of differing slopes. In addition, the relationship between dose and activity level was not the same for younger and older rats. The relationship between dosage of both d-amphetamine and methylphenidate and locomotor activity was not the same in the light and the dark. The latter finding suggests a difference between these two stimulants and the third stimulant studied, caffeine, whose effects where unaltered by ambient illumination level.
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This work was supported by research grant (MH 22140) from the National Institute of Mental Health.
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Kallman, W.M., Isaac, W. The effects of age and illumination on the dose-response curves for three stimulants. Psychopharmacologia 40, 313–318 (1975). https://doi.org/10.1007/BF00421469
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DOI: https://doi.org/10.1007/BF00421469