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The effects of stimulants and depressants on cocaine self-administration behavior in the Rhesus monkey

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Abstract

The effects of acute intramuscular pretreatment with several dosages of a variety of centrally acting compounds on intravenous cocaine self-administration behavior were ascertained. Pretreatment with morphine and pentobarbital produced no change in this behavior until dosages (2.0 mg/kg and 15.0 mg/kg respectively) were administered which grossly depressed grooming, exploratory, and locomotor activity behaviors, d-amphetamine (0.5–4.0 mg/kg) and phenmetrazine (2.0–12.0 mg/kg) pretreatment produced a dose-related decrease in cocaine self-administration. Trifluoperazine in dosages of 0.01–0.1 mg/kg increased the frequency of this behavior; whereas, higher dosages (0.2, 0.4 mg/kg) grossly depressed behavior. Imipramine (10–50 mg/kg) produced a dose-related decrease in cocaine self-administration. Potential mechanisms of these drug—behavior and drug—drug interactions are discussed.

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Author notes

  1. M. C. Wilson

    Present address: Department of Pharmacology, School of Pharmacy, University of Mississippi, University, 38677, Mississippi

  2. C. R. Schuster

    Present address: Departments of Psychiatry and Pharmacology, University of Chicago, 60637, Chicago, Illinois

Authors and Affiliations

  1. Pharmacology Department, University of Michigan Medical School, Ann Arbor, Michigan

    M. C. Wilson & C. R. Schuster

Authors
  1. M. C. Wilson
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  2. C. R. Schuster
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Additional information

This study was supported by NIMH Grant No. MH-12084 and by NIMH Grant No. MH-18245.

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Wilson, M.C., Schuster, C.R. The effects of stimulants and depressants on cocaine self-administration behavior in the Rhesus monkey. Psychopharmacologia 31, 291–304 (1973). https://doi.org/10.1007/BF00421274

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  • DOI: https://doi.org/10.1007/BF00421274

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