Skip to main content
SpringerLink
Log in

HLA-linked complement polymorphisms (C2, BF) in psoriasis

  • Original Contributions
  • Published:
Archives of Dermatological Research Aims and scope Submit manuscript

Summary

Starting from the known association between psoriasis and several HLA antigens and from the fact that the HLA chromosomal region contains the structural genes for at least three complement components, the authors have looked for an association between psoriasis and allotypes of C2 and BF. C2 and BF polymorphism were examined in 230 psoriatic patients. Two rare complement genes were found to be significantly increased when compared with controls: the frequency of the C2 *2 gene was 0.061 among patients and 0.035 among controls (P<0.05); for BF *SO7, the frequencies were 0.0304 in patients and 0.0092 in controls (P<0.0005). The BF *F gene frequency, however, was significantly decreased among patients: 0.1196 vs. 0.1743 (P<0.01). The relative risks were 1.79 for the C22, 3.44 for the BF SO7, and 0.6 for the BFF gene product. From previous studies, it is known that these three complement alleles (C2 *2, BF* SO7, BF *F) are in linkage disequilibrium with HLA alleles that have also been found increased or decreased, respectively, in psoriasis.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Allen FH Jr (1974) Linkage of HL-A and GBG. Vox Sang 27:382–384

    Google Scholar 

  2. Alper CA (1976) Inherited structural polymorphism in human C2: Evidence for genetic linkage between C2 and Bf. J Exp Med 144:1111–1115

    Google Scholar 

  3. Alper CA, Johnson AM (1969) Immunofixation clectrophoresis: A technique for the study of protein polymorphism. Vox Sang 17:445–452

    Google Scholar 

  4. Alper CA, Boenisch T, Watson L (1972) Genetic polymorphism in human glycine-rich beta-glycoprotein. J Exp Med 135:68–80

    Google Scholar 

  5. Bertrams J, Baur MP (1979) HLA-A, B, Bf three point association of 1,072 haplotypes in a German population. Tissue Antigens 14:317–324

    Google Scholar 

  6. Dewald G, Rittner C (1979) Polymorphism of the second component of human complement (C2). Observation of the rare phenotype C22 (=C2B) and data on the localization of the C2 locus in the HLA region. Vox Sang 37:47–54

    Google Scholar 

  7. Fu SM, Kunkel HG, Brusman HP, Allen FH, Fotino M (1974) Evidence for linkage between HL-A histocompatibility genes and those involved in the synthesis of the second component of complement. J Exp Med 140:1108–1111

    Google Scholar 

  8. Grosse-Wilde H, Wüstner H, Albert ED, Kuntz B, Scholz S, Braun-Falco O (1978) HLA-D typing in 72 psoriasis vulgaris patients: Distribution of seven HLA-D alleles. Tissue Antigens 11:427–433

    Google Scholar 

  9. Hawkins BR, Tiwari JL, Lowe N, Wolfish P, Pollock CA, Cho YW, Terasaki PI (1980) HLA and psoriasis, Joint report. In: Terasaki PI (ed) Histocompatibility testing 1980. The Regents of the University of California, Los Angeles, pp 711–714

    Google Scholar 

  10. Kimberling W, Dobson RL (1973) The inheritance of psoriasis. J Invest Dermatol 60:538–540

    Google Scholar 

  11. Lachmann PJ (1979) Complement. In: Sela M (ed) The antigens, vol V. Academic Press, New York San Francisco London, pp 283–353

    Google Scholar 

  12. Lachmann PJ, Hobart MJ (1978) Complement genetics in relation to HLA. Br Med Bull 34:247–252

    Google Scholar 

  13. Marcusson, J, Möller E, Thyresson N (1976) Penetration of HLA-linked psoriasis-predisposing gene(s): A family investigation. Acta Derm Venereol (Stockh) 56:453–463

    Google Scholar 

  14. Mauff G, Adam R, Wachauf B, Hitzeroth HW, Hiller C (1980) Serum concentration and functional efficiency of factor B alleles. Immunobiol 158:86–90

    Google Scholar 

  15. Mauff G, Federmann G, Hauptmann G (1980) A hemolytically inactive gene product of factor B. Immunobiol 158:96–100

    Google Scholar 

  16. Mauff G, Hauptmann G, Hitzeroth HW, Gauchel F, Scherz R (1978) The nomenclature of properdin factor B allotypes. Z Immun-Forsch 154:115–120

    Google Scholar 

  17. Mauff G, Hummel K, Pulverer G (1975) Properdin factor B (glycine-rich beta-glycoprotein or C3 proactivator)-polymorphism: Genetic and biochemical aspects. First application to paternity cases. Z Immun-Forsch 150:327–338

    Google Scholar 

  18. McMichael AJ, Morhenn V, Payne R, Sasazuki T, Farber EM (1978) HLA C and D antigens associated with psoriasis. Br J Dermatol 98:287–292

    Google Scholar 

  19. Meo T, Atkinson J, Bernoco M, Bernoco D, Ceppellini R (1976) Mapping of the HLA locus controlling C2 structural variants and linkage disequilibrium between alleles C22 and Bw 15. Eur J Immunol 6:916–919

    Google Scholar 

  20. Mortensen JP, Lamm LU (1981) Quantitative differences between complement factor-B phenotypes. Immunology 42:505–511

    Google Scholar 

  21. Olaisen B, Teisberg P, Gedde-Dahl T Jr, Thorsby E (1978) Genetic polymorphism of the second component of human complement (C2). Presentation of a modified typing technique and data on C2 phenotype distribution, linkage genetics, and haplotype associations in a Norwegian family material. Hum Genet 42:301–305

    Google Scholar 

  22. O'Neill GJ, Braun D Jr, Park MS, Dupont B (1980) HLA-linked genetic markers in HLA genotyped families. Joint report. In: Terasaki PI (ed) Histocompatibility testing 1980. The Regents of the University of California, Los Angeles, pp 142–147

    Google Scholar 

  23. Rittner C (1976) Genetic loci of components of the classical and alternate pathway of complement activation: A new dimension of the immunogenetic linkage group (HLA) on chromosome 6 in man. Hum Genet 35:1–20

    Google Scholar 

  24. Rittner C, Hauptmann G, Grosse-Wilde H, Grosshans E, Tongio MM, Mayer S (1975) Linkage between HL-A (major histocompatibility complex) and genes controlling the synthesis of the fourth component of complement. In: Kissmeyer-Nielsen F (ed) Histocompatibility testing 1975. Munksgaard, Copenhagen, pp 945–954

    Google Scholar 

  25. Russell TJ, Schultes LM, Kuban DJ (1972) Histocompatibility (HL-A) antigens associated with psoriasis. N Engl J Med 287:738–740

    Google Scholar 

  26. Ryder LP, Andersen E, Svejgaard A (eds) (1979) HLA and disease registry. Third report. Munksgaard, Copenhangen, pp 37–39

    Google Scholar 

  27. Teisberg P (1970) High voltage agarose gel electrophoresis in the study of C3 polymorphims. Vox Sang 19:47–56

    Google Scholar 

  28. Teisberg P, Olaisen B, Nordhagen R, Thorsby E, Gedde-Dahl T Jr (1980) A hemolytically non-active C4 gene product. Immunobiology 158:91–95

    Google Scholar 

  29. Thorsby E, Piazza A (1975) Joint report of the sixth International Histocompatibility Workshop Conference. II. Typing for HLA-D (LD 1 or MLC) determinants. In: Kissmeyer-Nielsen F (ed) Histocompatibility testing 1975. Munksgaard, Copenhagen, pp 414–458

    Google Scholar 

  30. Watson W, Cann HM, Farber EM, Nall ML (1972) The genetics of psoriasis. Arch Dermatol 105:197–207

    Google Scholar 

  31. White SH, Newcomer VD, Mickey MR, Terasaki PI (1972) Disturbance of HL-A antigen frequency in psoriasis. N Engl J Med 287:740–743

    Google Scholar 

  32. Williams RC, McKenzie AW, Roger JH, Joysey VC (1976) HL-A antigens in patients with guttate psoriasis. Br J Dermatol 95:163–167

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Dermatology, University of Bonn, D-5300, Bonn-Venusberg, Germany

    G. Dewald, C. -E. Lange, E. Schmeel & H. -W. Kreysel

Authors
  1. G. Dewald
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. -E. Lange
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. E. Schmeel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. H. -W. Kreysel
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Dewald, G., Lange, C.E., Schmeel, E. et al. HLA-linked complement polymorphisms (C2, BF) in psoriasis. Arch Dermatol Res 275, 301–304 (1983). https://doi.org/10.1007/BF00417201

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00417201

Key words

Search

Navigation