Abstract
A genetically heterogeneous (HS) group of mice and a highly inbred strain of mice (C57BL/6) were both shown to become highly susceptible to audiogenic seizures after exposure to acoustic stimulation (priming). In heterogeneous mice the optimal age for priming was 18 days with a test-retest interval of 48 hours. The optimal test-retest interval in C57BL/6 mice primed at 20 days of age was 8 days. One second of priming was found effective in enhancing seizure susceptibility. Drugs known to alter steady state levels of biogenic amines and to change responses of mice genetically predisposed to audiogenic seizures were found to be effective in altering seizure susceptibility from priming, but not effective in altering the priming itself.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Cohen, L. M., Karn, H. W.: The anti-convulsant action of dilantin on sound-induced seizures in the rat. J. comp. Psychol. 35, 307–310 (1943).
Coleman, D. L.: Phenylalanine hydroxylase activity in dilute and non-dilute strains of mice. Arch. Biochem. 91, 300–306 (1960).
Fuller, J. L., Collins, R. L.: Mice unilaterally sensitized for audiogenic seizures. Science 162, 1295 (1968).
Griffiths, W. J.: The effects of dilantin on convulsive seizures in the white rat. J. comp. Psychol. 33, 291–296 (1942).
Henry, K. R.: Audiogenic seizure susceptibility induced in C57BL/6J mice by prior auditory exposure. Science 158, 938–940 (1967).
Iturrian, W. B., Fink, G. B.: Conditioned convulsive reaction. Fed. Proc. 26, 736 (1967).
Lehmann, A.: Audiogenic seizures data in mice supporting new theories of biogenic amines mechanisms in the central nervous system. Life Sci. 6, 1423–1431 (1967).
McNemar, Q.: Psychological statistics, 3rd Edition. New York: John Wiley & Sons, Inc. 1962.
Schlesinger, K., Boggan, W. O., Freedman, D. X.: Genetics of audiogenic seizures: I. Relation of brain serotonin and norepinephrine in mice. Life Sci. 4, 2345–2351 (1965).
— — —: Genetics of audiogenic seizures: II. Effects of pharmacological manipulation of brain serotonin, norepinephrine and gamma-aminobutyric acid. Life Sci. 7, 437–447 (1968).
— — —: Genetics of audiogenic seizures: III. Time response relationships between drug administration and seizure susceptibility. Life Sci. 9, 721–729 (1970).
Sze, P. Y.: Neurochemical factors in auditory stimulation and development of susceptibility to audiogenic seizures. In: B. L. Welch and A. S. Welch (Eds.): Psysiological Effects of Noise. New York: Plenum Press 1970.
Author information
Authors and Affiliations
Additional information
This research was supported by research grants State of Illinois Public Welfare 17-302, National Institute of Mental Health MH 13026, USPHS MH No. 07083-08 and 09, and by a research fellowship (to R.A.L.) from the Schweppe Foundation.
Rights and permissions
About this article
Cite this article
Boggan, W.O., Freedman, D.X., Lovell, R.A. et al. Studies in audiogenic seizure susceptibility. Psychopharmacologia 20, 48–56 (1971). https://doi.org/10.1007/BF00404058
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF00404058