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Relation between the structure of certain methoxyphenylethylaminederivatives and the occurrence of a Hypokinetic Rigid Syndrome

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Summary

The experiments with 9 phenylethylamine-derivatives on cats confirm that the occupation of the para-position in the phenol-ring by an OCH3-group is essential to produce a Hypokinetic Rigid Syndrome (H.R.S.). Treating cats with molecular equivalent doses, the duration of this syndrome can be prolonged when OCH3-groups are occupying, apart from the para-position, other places adjacent to the paraposition as well. A striking parallelism of mydriasis and salivation with the H.R.S., both in duration and intensity, was noted.

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References

  • Axelrod, J.: O-methylation of epinephrine and other catechols in vitro and in vivo. Science 126, 400 (1957).

    Google Scholar 

  • Ernst, A. M.: Phenomena of the hypokinetic rigid type caused by O-methylation of dopamine in the para-position. Nature (Lond.) 193, 178–179 (1962a).

    Google Scholar 

  • —: Experiments with an O-methylated product of dopamine on cats. Acta physiol. pharmacol. neerl. 11, 48–53 (1962b).

    Google Scholar 

  • Friedhoff, A. J., and E. van Winkle: Isolation and characterization of a compound from the urine of schizophrenics. Nature (Lond.) 194, 867–868 (1962).

    Google Scholar 

  • — —: Conversion of dopamine to 3.4-dimethoxyphenylacetic acid in schizophrenic patients. Nature (Lond.) 199, 1271 (1963).

    Google Scholar 

  • Kuehl, F. A., M. Hichens, R. E. Ormond, M. A. P. Meisinger, P. H. Gale, V. J. Cirillo, and N. G. Brink: Para-O-methylation of dopamine in schizophrenic and normal individuals. Nature (Lond.) 203, 154–155 (1964).

    Google Scholar 

  • Magnus, R.: Körperstellung, p. 1–721. Berlin: Springer 1924.

    Google Scholar 

  • Sen, N. P., and P. L. McGeer: 4-Methoxyphenylethylamine and 3.4-dimethoxyphenylethylamine in human urine. Biochem. biophys. Res. Commun. 14, 227–232 (1964).

    Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacology, University of Utrecht, Utrecht, The Netherlands

    A. M. Ernst

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  1. A. M. Ernst
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Ernst, A.M. Relation between the structure of certain methoxyphenylethylaminederivatives and the occurrence of a Hypokinetic Rigid Syndrome. Psychopharmacologia 7, 383–390 (1965). https://doi.org/10.1007/BF00402360

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  • DOI: https://doi.org/10.1007/BF00402360

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