Abstract
In chronic spinal dogs, LSD, mescaline, psilocin, 2,5-dimethoxy-4-methylamphetamine, methysergide and tryptamine facilitate the flexor reflex evoked by tetanic electrical stimulation of the toe and induce the stepping reflex. These effects are antagonized by chlorpromazine and cyproheptadine, but not by phenoxybenzamine. 5-Hydroxytryptophan and serotonin also facilitate the flexor reflex and evoke the stepping reflex, but these effects are not antagonized by cyproheptadine. These findings suggest that the mode of action of several LSD-like psychotogens is similar to that of tryptamine and is different from that of serotonin or 5-hydroxytryptophan.
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A preliminary report of these data was presented at the fall meeting of the American Society for Pharmacology and Experimental Therapeutics, 1968, and was published in The Pharmacologist 10, 196 (1968).
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Martin, W.R., Eades, C.G. The action of tryptamine on the dog spinal cord and its relationship to the agonistic actions of LSD-like psychotogens. Psychopharmacologia 17, 242–257 (1970). https://doi.org/10.1007/BF00402084
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DOI: https://doi.org/10.1007/BF00402084