Summary
Eleven families with X-linked dominant hypophosphataemic rickets (HPDR) have been typed for a series of X chromosome markers. Linkage with probe 99.6 (DXS41) was demonstrated with a peak lod score of 4.82 at 10% recombination. Multilocus linkage analysis showed that HPDR maps distal to 99.6; this probe has previously been located at Xp22.31-p21.3 by in situ hybridisation. In the mouse hypophosphataemia (Hyp) maps to the distal part of the X chromosome; our location in man is consistent with a scheme which relates the mouse and human X chromosomes by two rearrangements. No marker has yet been found which shows no recombination with HPDR.
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Read, A.P., Thakker, R.V., Davies, K.E. et al. Mapping of human X-linked hypophosphataemic rickets by multilocus linkage analysis. Hum Genet 73, 267–270 (1986). https://doi.org/10.1007/BF00401242
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DOI: https://doi.org/10.1007/BF00401242