Summary
Experiments conducted on rabbits confirmed that chlorpromazine potentiates the weak epileptogenic action of Amipaque (metrizamide). Chlorpromazine withdrawal for a period of 48 h suppresses this potentiating effect in the rabbit. Neuroleptic drugs should therefore be avoided in patients examined with Amipaque. In patients under chronic treatment, neuroleptics ought to be discontinued at least 48 h before examination with Amipaque. With the doses and methods used in the present study, diazepam was not as effective as phenobarbital in preventing epilepsy produced by Amipaque. When premidication is needed or when convulsions occur after Amipaque examinations, combined diazepam and phenobarbital therapy ought to be instituted in order to achieve the best control of epileptic reactions.
Similar content being viewed by others
References
Booker, H. E., Gadstone, G. C.: Serum concentration of Diazepam in subjects with epilepsy. Arch. Neurol. 29, 192–194 (1973)
De Silva, A. F., Koechlin, B. A., Bader, G.: Blood level distribution patterns of Diazepam and its major metabolite in man. J. Pharm. Sci. 55, 692–702 (1966)
Gonsette, R. E.: Biological tolerance of the central nervous system to metrizamide. Acta radiol. Suppl. 335, 25–44 (1973)
Gonsette, R. E.: Metrizamide as contrast medium for myelography and ventriculography. Acta radiol. Suppl. 345, 346–358 (1973)
Grepe, A., Widen, L.: Neurotoxic effect of intracranial subarachnoid application of metrizamide and meglumine iocarmate. An experimental investigation in dogs in neurolept analgesia. Acta radiol. Suppl. 335, 102–118 (1973)
Hindmarsh, T., Grepe, A., Widen, L.: Metrizamide—phenothiazine interaction. Report of a case with seizures following myelography. Acta radiol. Diagn. 16, 129–134 (1975)
Kaada, B.: Transient EEG abnormalities following lumbar myelography with metrizamide. Acta radiol. Suppl. 335, 380–386 (1973)
Kaplan, S. A., Jack, M. L., Alexander, K., Weinfeld, R. E.: Pharmacokinetic profile of diazepam in man following single intravenous and oral and chronic oral administrations. J. Pharm. Sci. 62, 1789–1796 (1973)
Piwonka, R. W., Healey, J. F., Rosenberg, F. J.: Personal communication (1975)
Tilly: Personal communication (1974)
Wylie, I. G., Afshar, F., Koeze, T. H.: Results of the use of a new watersoluble contrast medium (metrizamide) in the posterior fossa of the baboon. Brit. J. Radiol. 48, 1007–1012 (1973)
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gonsette, R.E., Brucher, J.M. Potentiation of amipaque. Neuroradiology 14, 27–30 (1977). https://doi.org/10.1007/BF00399884
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF00399884