Summary
Concentrations of nine metals (Fe, Ca, Mg, Zn, Cu, Co, Ni, Pb and Cr) concentrations in lung tissues from 224 lung cancer cases were compared with those in other cases to achieve an understanding of their contribution to the development of lung cancer and the varieties after the development of cancer. Comparisons of metal concentrations in each cell type of lung cancer were also performed. All cases were collected from routine autopsies in Tokyo and Saitama, Japan. The copper concentration in tissue from lung cancers was significantly higher than that in other specimens, although calcium, magnesium, zinc and cobalt concentrations in lung cancers were significantly lower than those in other cases. There were no significant differences in the 99% intervals (excluding extremely high values for occupationally exposed cases) for chromium, nickel and lead concentrations between lung cancers and other cases, although these values were lower in lung cancers. However, in comparisons of men only, the chromium concentration, the degree of lung contamination and the severity of pulmonary emphysema in lung cancer cases were significantly higher than those in other specimens. Moreover, percentages of lung cancer in men at each degree of contamination and each severity of emphysema increased with increasing grades. Thus, this finding could be evidence that the exposure to contaminants other than chromium and nickel in the air had affected the development of lung cancer, except for occupationally exposed individuals. Therefore, almost all chromium and nickel in lung tissue might not deposit in carcinogenic forms such as hexavalent chromium or nickel subsulfide. Comparison of the characteristics in each cell type of lung cancer revealed that calcium and chromium concentrations in lung tissue (not including tumor) or squamous cell carcinomas were higher than those in the other cell types. In small cell carcinomas, calcium magnesium and zinc concentrations were low.
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References
Abe S, Ohsaki Y, Kimura K, Tsuneta Y, Mikami H, Murao M (1982) Chromate lung cancer with special reference to its cell type and relation to the manufacturing process. Cancer 49:783–787
Adachi S (1987) Effects of chromium compounds on the respiratory system, part 5. Jpn J Ind Health 29:17–33
Adachi S, Takemoto K (1987) Occupational lung cancer. Jpn J Ind Health 29:345–357
Anttila S, Kokkonen P, Pääkö P, Rainio P, Kalliomäki PL, Pallon J, Malmqvist K, Pakarinen P, Näntö V, Sutinen S (1989) High concentration of chromium in lung tissue from lung cancer patients. Cancer 63:467–473
De Flora S, Bagnasco M, Serra D, Zanacchi P (1990) Genotoxicity of chromium compounds, a review. Mutat Res 238:99–172
Fujii M (1990) Serum copper and zinc levels in patients with lung cancer. Med Biol 120:105–107
Hirayama T (1982) Epidemiological aspects of lung cancer in the orient. In: Ishikawa S, Hayata Y, Suemasu K (eds) Lung cancer 1982. Excerpta Medica, Amsterdam-Oxford-Princeton, pp 1–13
Huhti B (1980) Serum copper levels in patients with lung cancer. Respiration 40:112–116
Japan Lung Cancer Society (1987) General rule for clinical and pathological recording of lung cancer, 3rd edition. Kanehara, Tokyo
Kishi R, Tarumi T, Uchino E, Miyake H (1987) Chromium content or organs of chromate workers with lung cancer. Am J Ind Med 11:67–74
Kollmeier H, Witting C, Seemann J, Wittig P, Rothe R (1985) Increased chromium and nickel content in lung tissue. J Cancer Res Clin Oncol 110:173–176
Kreyberg L (1969) Aetiology of lung cancer. Universitersforlaget, Oslo
Ministry of Health and Welfare (1990) Health and welfare statistics in Japan. Health and Welfare Statistics Association, Tokyo
Nishiyama H, Yano H, Nishiwaki Y, Kitatani T, Mastuyama T, Tamai S, Kodama T, Suemasu K, Takemoto K (1986) Lung cancers in chromate workers. J Jpn Assoc Lung Cancer 26:125–135
Raithel HJ, Ebner G, Schellmann B, Valentin H (1987) Problems in establishing norm values for nickel and chromium in human pulmonary tissue. Am J Ind Med 12:55–70
Raithel HJ, Schaller KH, Reith A, Svenes KB, Valentin H (1988) Investigations on the quantitative determination of nickel and chromium in human lung tissue. Int Arch Occup Environ Health 60:55–66
Raithel HJ, Schaller KH, Akslen LA, Myking AO, Morkve O, Gulsvik A (1989) Analyses of chromium and chromium and nickel in human pulmonary tissue. Int Arch Occup Environ Health 61:507–512
Saitama Institute of Environmmmal Pollution (1982) Report of the Saitama Institute of Environmental Pollution, vol 9, Saitama Institute of Environmental Pollution, Saitama
Saitama Institute of Environmental Pollution (1985) Report of the Saitama Institute of Environmental Pollution, vol 12, Saitama Institute of Environmental Pollution, Saitama
Spencer H (1985) Pathology of the Lung 4th. ed. Pergamon Press, Oxford
Strain WM, Mansour E, Flynn A, Pories WJ, Tomaro AJ, Hill OA Jr (1972) Plasma zinc concentration in patients with bronchogenic cancer. Lancet 1:1021–1022
Takemoto K, Kawai H, Kuwahara T, Nishina M, Adachi S (1991) Metal concentrations in human lung tissue, with special reference to age, sex, cause of death, emphysema and contamination of lung tissue. Int Arch Occup Environ Health 62:579–586
Tokyo Metropolitan Research Institute for Environmental Protection (1972) Annual report of the Tokyo Metropolitan Research Institute for Environmental Protection vol 3, Tokyo Metropolitan Research Institute for Environmental Protection, Tokyo
Tokyo Metropolitan Research Institute for Environmental Protection (1987) Annual report of the Tokyo Metropolitan Research Institue for Environmental Protection vol 18, Tokyo Metropolitan Research Institute for Environmental Protection, Tokyo
Waldbott GL (1978) Health effects of environmental pollutants 2nd. ed. C.V. Mosby, St. Louis
Yendt ER (1972) Disorders of calcium, phosphorus and magnesium metabolism. In: Maxwell MH, Kleeman CR (eds) Disorders of fluid and electrolyte metabolism, 2nd ed. McGraw Hill, New York, pp 401–503
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Adachi, S., Takemoto, K., Ohshima, S. et al. Metal concentrations in lung tissue of subjects suffering from lung cancer. Int. Arch Occup Environ Heath 63, 193–197 (1991). https://doi.org/10.1007/BF00381568
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DOI: https://doi.org/10.1007/BF00381568