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Urinary excretion of chromium as an indicator of exposure to trivalent chromium sulphate in leather tanning

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Summary

Two workers exposed to trivalent chromium sulphate in a leather tannery had high concentrations of chromium in the urine. The concentration of chromium showed a workshift-related diurnal fluctuation, but it was remarkably high even after a vacation, indicating accumulation of chromium in the body. The concentrations of chromium in the workplace air, as collected on filters using standard techniques, were below 30/gmg/m3. The chromium in the air was present in the form of large droplets not collected by the standard techniques. In the blood stream, chromium was transported exclusively in the plasma. No absorption of chromium through the skin could be detected. Absorption from the gastrointestinal tract was calculated to explain the findings.

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References

  1. Aaseth J, Alexander J, Norseth T (1982) Uptake of 51chromate by human erythrocytes—a role of glutathione. Acta Pharmacol Toxicol 50:310–315

    Google Scholar 

  2. Anderson RA, Polansky MM, Bryden NA, Patterson KY, Veillon C, Glinsman WH (1983) Effects of chromium supplementation on urinary Cr excretion of human subjects and correlation of Cr excretion with selected clinical parameters. J Nutr 113:276–281

    Google Scholar 

  3. Baselt RC (1980) Biological monitoring methods for industrial chemicals. Biomedical Publications, Davis, California, p 301

    Google Scholar 

  4. Berode M, Guillemin M (1977) Evaluation d'une exposition professionelle au chrome par le dosage du chrome urinaire. Med Soc Prev 22:201–202

    Google Scholar 

  5. Bulikowski W, Tyras H (1976) Dermatological evaluation of occupational exposure of tanners to chromium compounds. Berufsdermatosen 24:132–137

    Google Scholar 

  6. Gray SJ, Sterlins K (1950) The tagging of red cells and plasma proteins with radioactive chromium. J Clin Invest 29:1604–1613

    Google Scholar 

  7. Gylseth B, Gunderse N, Langård S (1977) Evaluation of chromium exposure based on a simplified method for urinary chromium determination. Scand J Work Eviron Health 3:28–31

    Google Scholar 

  8. Hayes RB (1982) Carcinogenic effects of chromium. In: Langård S (ed) Biological and environmental aspects of chromium. Elsevier, Amsterdam, pp 221–247

    Google Scholar 

  9. IARC (1980) IARC monographs on the evaluation of the carcinogenic risk of chemicals to humans, vol 23:205–323

  10. Kalliomäki P-L, Rahkonen E, Vaaranen V, Kalliomäki K, Aittoniemi K (1981) Lung-retained contaminants, urinary chromium and nickel among stainless steel welders. Int Arch Occup Environ Health 49:67–75

    Google Scholar 

  11. Kelly WF, Ackrill P, Day JP, O'Hara M, Tye CT, Burton I, Orton C, Harris M (1982) Cutaneous absorption of trivalent chromium: tissue levels and treatment by exchange transfusion. Br J Ind Med 39:397–400

    Google Scholar 

  12. Kiilunen M, Kivistö H, Ala-Laurila P, Tossavainen A, Aitio A (1983) Exceptional pharmacokinetics of trivalent chromium during occupational exposure to chromium lignosulfonate dust. Scand J Work Environ Health 9:265–271

    Google Scholar 

  13. Kitagawa S, Seki H, Kametani F, Sakurai H (1982) Uptake of hexavalent chromium by bovine erythrocytes and its interaction with cytoplasmic contents; the role of glutathione. Chem Biol Interact 40:265–274

    Google Scholar 

  14. Korallus U, Ehrlicher H, Wustefeld E (1974) Dreiwertige Chromverbindungen: Ergebnisse einer arbeitsmedizinischen Untersuchung. Arbeitsmed Sozialmed Präventivmed 11:248–252

    Google Scholar 

  15. Kumpulainen J, Lehto J, Koivistoinen P, Uusitupa M, Vuori E (1983) Determination of chromium in human milk, serum and urine by electrothermal atomic absorption spectrometry without preliminary ashing. Sci Tot Environ 31:71–80

    Google Scholar 

  16. Langård S (1982) Absorption, transport and excretion of chromium in man and animals. In: Langård S (ed) Biological and environmental aspects of chromium. Elsevier, Amsterdam, pp 149–160

    Google Scholar 

  17. Lauwerys RR (1983) Industrial chemical exposure: guidelines for biological monitoring. Biomedical Publications, Davis, California, p 150

    Google Scholar 

  18. Levis AG, Bianchi V (1982) Mutagenic and cytogenetic effects of chromium compounds. In: Langard S (ed) Biological and environmental aspects of chromium. Elsevier, Amsterdam, pp 171–208

    Google Scholar 

  19. Lim TH, Sargent III T, Kusubov N (1983) Kinetics of trace element chromium (III) in the human body. Am J Physiol 244:R445–454

    Google Scholar 

  20. Minoia C, Cavalleri A, D'Andrea F (1983) Urinary secretion of total and hexavalent chromium in workers exposed to trivalent and hexavalent chromium. In: Brätter P, Schrammel P (eds) Trace element analytical chemistry in medicine and biology. De Gruyter, Berlin, pp 623–626

    Google Scholar 

  21. Mutti A, Cavatorta A, Pedroni C, Borghi A, Giaroli C, Franchini I (1979) The role of chromium accumulation in the relationship between airborne and urinary chromium in welders. Int Arch Occup Environ Health 43:123–133

    Google Scholar 

  22. Pedersen NB (1982) The effects of chromium on the skin. In: Langård S (ed) Biological and environmental aspects of chromium. Elsevier, Amsterdam, pp 249–275

    Google Scholar 

  23. Rahkonen E, Junttila M-L, Kalliomäki P-L, Olkinuora M, Koponen M, Kalliomäki K (1983) Evaluation of biological monitoring among stainless steel welders. Int Arch Occup Environ Health 52:243–255

    Google Scholar 

  24. Sjögren B, Hedström L, Ulfvarson U (1983) Urine chromium as an estimator of air exposure to stainless steel welding fumes. Int Arch Occup Environ Health 51:347–354

    Google Scholar 

  25. Tandon SK (1982) Organ toxicity of chromium in animals. In: Langård S (ed) Biological and environmental aspects of chromium. Elsevier, Amsterdam, pp 209–220

    Google Scholar 

  26. Tandon SK, Mathur AK, Gaur JS (1977) Urinary excretion of chromium and nickel among electroplaters and pigment industry workers. Int Arch Occup Environ Health 40:71–76

    Google Scholar 

  27. Tola S, Kilpiö J, Virtamo M, Haapa K (1977) Urinary chromium as an indicator of the exposure of welders to chromium. Scand J Work Environ Health 3:192–202

    Google Scholar 

  28. Welinder H, Littorin M, Gullberg B, Skerfving S (1983) Elimination of chromium in urine after stainless steel welding. Scand J Work Environ Health 9:397–403

    Google Scholar 

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Aitio, A., Järvisalo, J., Kiilunen, M. et al. Urinary excretion of chromium as an indicator of exposure to trivalent chromium sulphate in leather tanning. Int. Arch Occup Environ Heath 54, 241–249 (1984). https://doi.org/10.1007/BF00379053

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  • DOI: https://doi.org/10.1007/BF00379053

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