Summary
In a climatic exposure chamber four healthy volunteers were exposed to 100ppm toluene, 100ppm toluene + ethanol, 100ppm toluene + cimetidine, and 100ppm toluene + propranolol for 7h each at random over four consecutive days. A control experiment and 3.5 h of exposure to 200 ppm toluene were also performed. Ethanol inhibited toluene metabolism by 0.5 as expressed by the urinary excretion of two of the metabolites of toluene, namely o-cresol and hippuric acid. In agreement with this, the mean alveolar concentration of toluene was greater by 1.7 during ethanol exposure; 45 min after discontinuation of exposure the increase was by 3.3. Neither cimetidine nor propranolol changed toluene metabolism significantly. The results indicate that ethanol may prolong the time interval in which toluene is retained in the human body in persons simultaneously exposed to ethanol and toluene. When using o-cresol or hippuric acid in biological monitoring of persons occupationally exposed to toluene, the consumption of ethanol should be considered.
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Døssing M, Bælum J, Hansen SH, Lundqvist GR, Andersen NT (1983) Urinary hippuric acid and ortho cresol excretion in man during experimental exposure to toluene. Br J Ind Med 40:470–473
Greenblatt DJ, Franke K, Huffman (1978) Impairment of antipyrine clearance in humans by propranolol. Circulation 57:1161–1164
Hansen SH, Døssing M (1982) Determination of urinary hippuric acid and O-cresol as indices of toluene exposure by liquid chromatography on dynamically modified silica. J Chromatogr 229:141–148
Müller G, Spassowski M, Henchler D (1975) Metabolism of trichloroethylene in man III. Interaction of trichloroethylene and ethanol. Arch Toxicol 33:173–189
Riihimäki V, SavolainenSM, Pfäffli P, Pekari K, Sippel HW, Laine A (1982) Metabolic interaction between m-xylene and ethanol. Arch Toxicol 49:253–263
Sellers EM, Holloway MR (1978) Drug kinetics and alcohol ingestion. Clin Pharmacokinet 3:440–452
Seppälainen AM, Savolainen K, Kavala T (1981) Changes induced by xylene and alcohol in human evoked potentials. Electroencephal Clin Neurophysiol 51:148–155
Serlin MJ, Mossman S, Sibeon RG, Breckenridge AM (1979) Cimetidine: interaction with oral anticoagulants in man. Lancet ii:317–319
Waldron HA, Cherry N, Johnsberry JD (1983) The effects of ethanol on blood toluene concentrations. Int Arch Occup Environ Health 51:305–309
Wilson HK, Robertson SM, Waldron HA, Comperetz D (1983) Effect of alcohol on the kinetics of mandelic acid excretion in volunteers exposed to styrene vapour. Br J Ind Med 40:75–80
Windemuller FJB, Etteme (1978) Effects of combined exposure to trichloroethylene and alcohol on mental capacity. Int Arch Occup Environ Health 41:77–85
Woiwode W, Wodrarz R, Drych K, Weichardt H (1979) Metabolism of toluene in man: gaschromatographic determination of o-, m-, and p-cresol in urine. Arch Toxicol 43:93–98
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Supported by grants from the Working Environment Fund, Denmark
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Døssing, M., Bælum, J., Hansen, S.H. et al. Effect of ethanol, cimetidine and propranolol on toluene metabolism in man. Int. Arch Occup Environ Heath 54, 309–315 (1984). https://doi.org/10.1007/BF00378584
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DOI: https://doi.org/10.1007/BF00378584