Summary
Using a recently developed noninvasive, in vivo suction device for measuring skin elasticity, we evaluated age, sex, and regional differences in the viscoelastic properties of skin. A total of 33 volunteers participated in the study consisting of (a) 8 young females, (b) 9 old females, (c) 8 young males and (d) 8 old males. Measurements were performed on 11 anatomical regions; three different loads were applied: 100,200, and 500 mbar. The parameters used were: immediate distension (Ue); delayed distension (Uv); immediate retraction (Ur); and, final deformation (Uf). To compare between subjects and anatomical regions, relative parameters independent of skin thickness were calculated: Uv/Ue, the ratio between the viscoelastic properties of skin and immediate distension, and Ur/Uf, which measures the ability of the skin to regain its initial position after deformation. Generally, Uv/Ue increased while Ur/Uf decreased with aging. Responses were variable with respect to load applied. Variability within anatomical regions was also noted. However, differences between the sexes were not statistically significant for most regions. These findings are in congruence with earlier studies suggesting the differences are mainly attributable to alterations in the elastic fiber network. This procedure provides a simple, quantitative assessment of elastic properties of the skin. Its application may help in future investigations of other connective tissue disorders.
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References
Agache P, Honneur C, Leveque JL, de Rigal J (1980) Mechanical properties and Young's modulus of human skin in vivo. Arch Dermatol Res 269:221–232
Baker MR, Bader DL, Hopewell JW (1988) An apparatus for testing of mechanical properties of skin in vivo: its application to the assessment of normal and irradiated pig skin. Bioeng Skin 4:87–103
Balin AK, Pratt LA (1989) Physiological consequences of human skin aging. Cutis 43:431–436
Berardesca E, Borroni G, Gabba P, Borlone R, Rabbiosi G (1985) Evidence for elastic changes in aged skin revealed in an in vivo extensometric study at low loads. Bioeng Skin 2:261–270
Bjerring P (1985) Skin elasticity measured by dynamic admittance. A new technique for mechanical measurements in patients with scleroderma. Acta Derm Venereol [Suppl] (Stockh) 120:83–87
Bouissou H, Pieraggi M, Julian M, Savit T (1988) The elastic tissue of the skin: a comparison of spontaneous and actinic (solar) aging. Int J Dermatol 27(5):327–335
Bramont C, Vasselet R, Rochefort A, Agache P (1988) Mechanical properties of the skin in Marfan's syndrome and Ehlers-Danlos syndrome. Bioeng Skin 4:217–227
Burlin TE, Hutton WC, Eng C, Ranu RS (1977) A method of in vivo measurement of the elastic properties of skin in radiotherapy patients. J Invest Dermatol 69:321–323
Christensen MS, Hargens CW, Nacht S, Gans EH (1977) Viscoelastic properties of intact human skin: instrumentation, hydration effects, and the contribution of the stratum corneum. J Invest Dermatol 69:282–286
Daly CH, Odland GF (1979) Age-related changes in the mechanical properties of human skin. J Invest Dermatol 73:84–87
de Rigal J, Leveque JL (1985) In vivo measurement of the stratum corneum elasticity. Bioeng Skin 1:13–23
Elsner P, Wilhelm D, Maibach HI (1990) Mechanical properties of human vulvar skin. Br J Dermatol (in press)
Fazio MJ, Olsen DR, Uitto JJ (1989) Skin aging: lessons from cutis laxa and elastoderma. Cutis 43:437–444
Jagtman BA (1983) Clinical investigation of skin elasticity. An in vivo study of patients with varicose veins and certain connective tissue disorders. Thesis, Nijmegen, The Netherlands, pp 16–32
Johnston KJ, Oikarinen A, Lowe NJ (1985) Ultraviolet-induced connective tissue changes in the skin: models for actinic damage and cutaneous aging. In: Maibach HI, Lowe NJ (eds) Models in dermatology, vol 1. S Karger, Basel, Switzerland, pp 69–76
Leveque JL (1987) In vivo methods for measuring the viscoelastic properties of the skin. Bioeng Skin 3:375–382
Leveque JL, de Rigal J, Agache PG, Monneur C (1980) Influence of ageing on the in vivo extensibility of human skin at a low stress. Arch Dermatol Res 269:127–135
Patrick E, Maibach HI (1989) Dermatotoxicology. In: Hayes AW (ed) Principles and methods of toxicology. Raven Press, New York, p 384
Pierard GE (1989) A critical approach to in vivo mechanical testing of the skin. In: Leveque JL (ed) Cutaneous investigation in health and disease. Dekker, New York Basel, pp 215–240
Pierard GE (1989) Histological and rheological grading of cutaneous sclerosis in scleroderma. Dermatologica 179:18–20
Pierard GE, Lapiere CM (1977) Physiopathological variations in the mechanical properties of skin. Arch Dermatol Res 260:231–239
Serban G, Edelberg R, Garcia M, Hambridge A (1986) Intraepidermal sweat levels and the viscoelastic properties of human skin. Bioeng Skin 2(2):134
Serup J (1986) In vivo measurement of skin elasticity. In: Localized scleroderma (Morphea). Acta Derm Venereol [Suppl] (Stockh) 122:18–23
Serup J, Northeved A (1985) Skin elasticity in localized scleroderma (Morphoea). J Dermatol 12:52–62
Serup J, Northeved A (1985) Skin elasticity in psoriasis. In vivo measurement of tensile distensibility, hysteresis and resilient distension with a new method. Comparison with skin thickness as measured with high-frequency ultrasound. J Dermatol 12:318–324
Smith LS (1989) Histopathologic characteristic and ultrastructure of aging skin. Cutis 43:414–424
Uitto J, Oikarinen A, Thody AJ (1986) Mechanical and physical functions of the skin. In: Thody AJ, Friedman PS (eds) Scientific basis of dermatology. A physiological approach. Churchill-Livingstone, New York, pp 7–25
Uitto JJ, Jazio MJ, Olsen DR (1989) Molecular mechanisms of cutaneous aging. J Am Acad Dermatol 21:614–622
Vogel HG (1974) Correlation between tensile strength and collagen content in rat skin. Effect of age and cortisol treatment. Connect Tissue Res 2:177–182
Vogel HG (1981) Directional variations of mechanical parameters in rat skin depending on maturation and age. J Invest Dermatol 76:493–497
Vogel HG (1985) Age dependence of viscoelastic properties in rat skin; directional variations in relaxation experiments. Bioeng Skin 1:157–173
Vogel HG (1987) Age dependence of mechanical and biochemical properties of human skin. Part I: stress-strain experiments, skin thickness and biochemical analysis. Bioeng Skin 3:67–91
Vogel HG, Denkel K (1985) Influence of maturation and age, and of desmotropic compounds on the mechanical properties of rat skin in vivo. Bioeng Skin 1:35–54
Zar JH (1974) Biostatistical analysis. Prentice-Hall, Englewood Cliffs, N. J.
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Cua, A.B., Wilhelm, K.P. & Maibach, H.I. Elastic properties of human skin: relation to age, sex, and anatomical region. Arch Dermatol Res 282, 283–288 (1990). https://doi.org/10.1007/BF00375720
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DOI: https://doi.org/10.1007/BF00375720