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Interrelationships of the “Ly-6 complex” antigens

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Abstract

Competitive binding studies and immunoprecipitation experiments define at least five distinct epitopes encoded by Ly-6-linked genes—Ly-6A.2, Ly-6B.2, Ly-6C.2, Ly-6D.2, and ThB. Ly-6A.2, a 33 kd protein, and Ly-6D.2 are closely overlapping epitopes that can be distinguished by their unique thymus reactions of 10–20% or >90%, respectively. Similarly, the Ly-6C.2 antigen present on a 14 kd moiety loosely overlaps the Ly-6B.2 antigen. Ly-6C.2 and Ly-6B,2 antigens are distinct from Ly-6A.2 and Ly-6B.2, however. ThB is a 16–18 kd antigen which is not associated on the cell surface with any other “Ly-6” antigens. In addition, independently derived antibodies made to the Ly-6C.2 antigen detect an identical epitope, as do antibodies to Ly-6A.2 and Ly-6B.2. These results imply the existence of a single antigenic site on each of these molecules.

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Authors and Affiliations

  1. Research Centre for Cancer and Transplantation, Department of Pathology, University of Melbourne, 3052, Parkville, Victoria, Australia

    Bronwyn A. Houlden, P. Mark Hogarth & Ian F. C. McKenzie

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  1. Bronwyn A. Houlden
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  2. P. Mark Hogarth
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  3. Ian F. C. McKenzie
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Houlden, B.A., Hogarth, P.M. & McKenzie, I.F.C. Interrelationships of the “Ly-6 complex” antigens. Immunogenetics 23, 226–232 (1986). https://doi.org/10.1007/BF00373017

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  • DOI: https://doi.org/10.1007/BF00373017

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