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Proteins immunologically related to erythrocyte anion transporter band 3 are altered in brain areas affected by Alzheimer's disease

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Abstract

Proteins immunologically related to the human erythrocyte anion transporter band 3 are present in neurons of the human neocortex and hippocampus. Immunocytochemical studies show increased band 3 immunoreactivity in neurons in the brains of patients with Alzheimer's disease. Immunoblot studies show the presence of band 3-like molecules in brain membrane fractions, and suggest changes in expression and/or processing of band 3-like molecules in Alzheimer's disease-affected regions. We postulate that alterations in membrane-bound, band 3-like molecules may reflect termination of neuronal lifespan in Alzheimer's disease.

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Authors and Affiliations

  1. Department of Biochemistry, Faculty of Medicine, University of Nijmegen, P.O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    G. J. C. G. M. Bosman, I. G. P. Bartholomeus & W. J. De Grip

  2. Research Laboratory for Morphological Neurology, Institute of Neurology, University of Nijmegen, P.O. Box 9101, NL-6500 HB, Nijmegen, The Netherlands

    F. P. A. Van Workum & K. Renkawek

  3. Psychogeriatric Nursing Home “St. Joachim en Anna”, Nijmegen, The Netherlands

    P. J. C. Van Kalmthout

Authors
  1. G. J. C. G. M. Bosman
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  2. F. P. A. Van Workum
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  3. K. Renkawek
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  4. P. J. C. Van Kalmthout
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  5. I. G. P. Bartholomeus
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  6. W. J. De Grip
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Bosman, G.J.C.G.M., Van Workum, F.P.A., Renkawek, K. et al. Proteins immunologically related to erythrocyte anion transporter band 3 are altered in brain areas affected by Alzheimer's disease. Acta Neuropathol 86, 353–359 (1993). https://doi.org/10.1007/BF00369447

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  • DOI: https://doi.org/10.1007/BF00369447

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