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Coronarvasomotorik unter l-Noradrenalin und Isopropylnoradrenalin nach Blockierung der adrenergischen β-Receptoren durch Nethalide

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Abstract

1. The left coronary artery (ramus descendens or circumflexus) was cannulated and perfused with constant pressure. Phasic blood flow was measured by an electromagnetic This method allowed estimation of vasomotor activity within the coronary bed by means of recording enddiastolic blood flow.

2. Marked dilations of perfused coronary vessels were caused by intracoronary infusions of isoproterenol as well as noradrenaline.

3. Intravenous administration of the β-receptor-blocking agent Nethalide was accompanied by a reduction in enddiastolic flow.

4. After blocking the β-receptors, the isoproterenol induced dilation of coronary vessels was greatly diminished, whereas noradrenaline now led to vasoconstriction.

5. The results suggest that α-receptors exist within the coronary bed. Noradrenaline has a dual coronary vasomotor action: the constrictory effect (mediated by α-receptors) is normally exceeded by the greater dilatory effect (mediated by β-receptors). Because of its dual influence it is believed that under physiological conditions Noradrenaline takes part in regulation of coronary vasomotor tone.

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Authors and Affiliations

  1. Aus dem Physiologischen Institut der Universität Göttingen, Germany

    U. Doutheil, H. G. ten Bruggencate & K. Kramer

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  1. U. Doutheil
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  2. H. G. ten Bruggencate
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  3. K. Kramer
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Mit 4 Textabbildungen

Vorläufige Ergebnisse wurden auf der 29. Tagung der Deutschen Physiol. Gesellschaft in Bad Nauheim vorgetragen7.

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Doutheil, U., ten Bruggencate, H.G. & Kramer, K. Coronarvasomotorik unter l-Noradrenalin und Isopropylnoradrenalin nach Blockierung der adrenergischen β-Receptoren durch Nethalide. Pflügers Archiv 281, 181–190 (1964). https://doi.org/10.1007/BF00363626

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  • DOI: https://doi.org/10.1007/BF00363626

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