Summary
In newborn and older cold-adapted guinea pigs, who dispose of non-shivering thermogenesis, the extent of the cold-induced non-shivering oxygen-uptake (as judged from electromyography) was compared with the rise of oxygen uptake elicited by noradrenaline injection. It was demonstrated thereby that there are of, approximatively, the same size the maximum amounts of non-shivering thermogenesis which are evoked by either a natural cold stimulus or by a noradrenaline injection of an optimum dosage. The maximum effect of noradrenaline was obtained at neutral temperature. With decreasing environmental temperature the rise in oxygen-uptake evokable by noradrenaline was reduced by an extent that was equal to the rise of oxygen uptake which had already been evoked by the cold stimulus. The effects of both stimuli, cold and noradrenaline, could be suppressed by a β-receptor blocking agent. It was concluded from these results that the non-shivering thermogenesis in the guinea pig is essentially due to a catecholamine-mediated mechanism.
Zusammenfassung
Bei neugeborenen und älteren kälteadaptierten Meerschweinchen, die über zitterfreie Thermogenese verfügen, wurde das Ausmaß der kälteinduzierten zitterfreien O2-Aufnahme (elektromyographisch kontrolliert) mit der Steigerung der O2-Aufnahme verglichen, die durch Noradrenalin-Injektion auszulösen ist. Dabei ergab sich, daß der durch maximalen natürlichen Kaltreiz und der durch eine optimale Noradrenalindosis hervorzurufende Betrag an zitterfreier Thermogenese annähernd gleich groß sind. Der Noradrenalineffekt war am größten bei Neutraltemperatur. Mit sinkender Umgebungstemperatur nahm die durch Noradrenalininjektion hervorzurufende O2-Aufnahmesteigerung um den Betrag ab, der der durch Kältebelastung bereits hervorgerufenen O2-Aufnahmesteigerung entsprach. Die Effekte beider Reize, Kälte und Noradrenalin, konnten durch β-Receptorenblocker unterdrückt werden. Aus den Befunden wird gefolgert, daß die zitterfreie Thermogenese beim Meerschweinchen ausschließlich auf einem Katecholaminvermittelten Mechanismus beruht.
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Zeisberger, E., Brück, K. Quantitative Beziehung zwischen Noradrenalin-Effekt und Ausmaß der zitterfreien Thermogenese beim Meerschweinchen. Pflügers Archiv 296, 263–275 (1967). https://doi.org/10.1007/BF00362528
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DOI: https://doi.org/10.1007/BF00362528