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Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse Chromosome 4

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Abstract

The Friend virus susceptibility-1 (Fvl) gene maps to mouse Chromosome (Chr) 4 close to a cluster of four endogenous murine leukemia viruses (MLVs). To investigate the feasibility of cloning Fvl by a positional approach, we have performed an extensive genetic analysis of this region of Chr 4. We have typed 368 backeross mice for the four proviruses, Nppa, Lck, and D4Smh6b. Recombinant animals were screened in a hierarchical fashion with a variety of other markers, including Fvl and the isozyme marker Gpd1. A detailed genetic map of the region surrounding Fvl was derived. Three markers, Xmv9, Nppa, and Iap3rc11, were identified that showed no recombination with Fvl. By combining backcross and recombinant inbred strain data, we estimated that Xmv9 and Nppa must lie within 0.6 cM of one another and Fvl.

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Author notes

  1. N. Kaushik

    Present address: Institut Cochin de Genetique Moleculaire, 22 rue Mechain, 75014, Paris, France

  2. S. Best

    Present address: Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany

Authors and Affiliations

  1. National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK

    J. P. Stoye, N. Kaushik & S. Best

  2. MRC Human Biochemical Genetics Unit, The Galton Laboratory, University College London, Wolfson House, 4 Stephenson Way, NW1 2HE, London, UK

    S. Jeremiah

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Stoye, J.P., Kaushik, N., Jeremiah, S. et al. Genetic map of the region surrounding the retrovirus restriction locus, Fv1, on mouse Chromosome 4. Mammalian Genome 6, 31–36 (1995). https://doi.org/10.1007/BF00350890

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  • DOI: https://doi.org/10.1007/BF00350890

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