Abstract
A case of late-onset manifestation of organophosphorous insecticide poisoning is described. The patient was a 70-year-old female who ingested 40ml Sumithion emulsion (50% fenitrothion). At first, no toxic symptoms were apparent. However, 48 h after ingestion certain signs became apparent. An impediment in consciousness was observed. Fasciculation and muscular weakness were noted, while plasma and urinary 4-nitro-3-methylphenol (NMC), the degradation product of Sumithion, reached a maximum. Neither atropine sulfate nor PAM (pyridine 2-aldoxime methiodine) were effective. For 3 weeks the patient required ventilatory support, and consequently her muscle strength and neurological status gradually recovered with falling NMC levels.
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Sakamoto, T., Sawada, Y., Nishide, K. et al. Delayed neurotoxicity produced by an organophosphorous compound (Sumithion). Arch Toxicol 56, 136–138 (1984). https://doi.org/10.1007/BF00349087
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DOI: https://doi.org/10.1007/BF00349087