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Allelic variants of Ly-5 in inbred and natural populations of mice

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Abstract

Allelic variants of Ly-5 in inbred commensal and other natural populations of mice were analyzed by patterns of restriction fragment length polymorphisms (RFLP) and Southern hybridization using an Ly-5 cDNA probe and by cell-surface staining with a panel of antibodies directed against polymorphic and nonpolymorphic Ly-5 determinants. New Ly-5 alleles were defined by RFLPs generated by both Eco RI and Bam HI restriction enzyme digests. The Mus musculus subspecies and other species within the genus Mus showed a strong correlation between allelic variants defined by restriction enzymes and serologic specificities. The data also suggest the conservation of the Ly-5 gene throughout the genus Mus.

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Authors and Affiliations

  1. Cellular Immunology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases, National Institutes of Health, 20892, Bethesda, MD, USA

    Michael F. Seldin & Alfred D. Steinberg

  2. Laboratory of Genetics, National Cancer Institute, National Institutes of Health, 20892, MD, USA

    Lawrence A. D'Hoostelaere

  3. Memorial Sloan Kettering Cancer Center, 10021, New York, NY, USA

    Yumiko Saga

  4. Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 20892, Bethesda, MD, USA

    Herbert C. Morse III

Authors
  1. Michael F. Seldin
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  2. Lawrence A. D'Hoostelaere
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  3. Alfred D. Steinberg
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  4. Yumiko Saga
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  5. Herbert C. Morse III
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Seldin, M.F., D'Hoostelaere, L.A., Steinberg, A.D. et al. Allelic variants of Ly-5 in inbred and natural populations of mice. Immunogenetics 26, 74–78 (1987). https://doi.org/10.1007/BF00345457

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  • DOI: https://doi.org/10.1007/BF00345457

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