Summary
Dawson (1952) showed that, in Rana, many nerve terminals end round the capillaries of the venous portal system of the median eminence. Our observations not only confirm these facts but show as well that, besides the posterior lobe, the outer zone of the median eminence is also a centre of accumulation of neurosecretory material derived from the pre-optic nucleus. The amount of this neurosecretory material is moreover subject to a certain variation in connection with the seasons and with experimental conditions. The idea is put forward that the outer zone of the median eminence of Rana has to be considered as an analogical organ of the posterior lobe. Indeed, in the median eminence, the same morphological facts can be found, which are advanced for the conception that the posterior lobe is a centre of accumulation and a place of release of neurosecretory material originating from the pre-optic nucleus. On the basis of our observations we presume that the hypothalamo-hypophyseal neurosecretory system of Rana can be divided in two sub-units. System I ends in the posterior lobe; system II in the outer zone of the median eminence. The data of the literature indicate that the two systems also probably exist in the higher vertebrates. From these facts it is obvious that the neurosecretory material is transported from the pre-optic nucleus, via the tract, towards the outer zone of the median eminence.
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References
Assenmacher, I.: Recherches sur le contrôle hypothalamique de la fonction gonadotrope préhypophysaire chez le canard. Arch. Anat. micr. Morph. exp. 47, 447–572 (1958).
Assenmacher, I., et J. Benoit: Contribution à l'étude des relations de la substance Gomori-positive avec le complexe hypophysaire et la gonado-stimulation chez le canard domestique. C. R. Acad. Sci. (Paris) 236, 133–135 (1953).
—: Quelques aspects du contrôle hypothalamique de la fonction gonadotrope de la préhypophyse. Pathophys. dienceph., p. 401–427. Wien: Springer 1958.
Bargmann, W.: Über die neurosekretorische Verknüpfung von Hypothalamus und Neurohypophyse. Z. Zellforsch. 34, 610–634 (1949).
—: Die elektive Darstellung einer marklosen diencephalen Bahn. Mikroskopie 5, 289–292 (1950).
—: Neurosekretion und hypothalamisch-hypophysäres System. Anat. Anz. (Erg.-Heft) 100, 30–45 (1954).
—: Das Zwischenhirn-Hypophysensystem. Berlin: Springer 1954.
—: Weitere Untersuchungen am neurosekretorischen Zwischenhirn-Hypophysensystem. Z. Zellforsch. 42, 247–272 (1955).
Benoit, J., et I. Assenmacher: Rapports entre la stimulation sexuelle préhypophysaire et la neurosécrétion chez l'oiseau. Arch. Anat. micr. Morph. exp. 42, 334–386 (1953).
—: Le contrôle hypothalamique de l'activité préhypophysaire gonadotrope. J. Physiol. (Paris) 47, 427–567 (1955).
Dawson, A. B.: Hypothalamo-hypophysial relationships in Rana pipiens demonstrated by Gomori's chromalum hematoxylin method. Anat. Rec. 112, 443–444 (1952).
—: Evidence for the termination of neurosecretory fibers within the pars intermedia of the hypophysis of the frog, Rana pipiens. Anat. Rec. 115, 63–69 (1953).
Diepen, R.: Vergleichend-anatomische Untersuchungen über das Hypophysen-Hypothalamus-System bei Amphibien und Reptilien. Anat. Anz. (Erg.-Heft) 99, 79–89 (1952).
Drager, G. A.: The innervation of porpoise pituitary gland with special emphasis on the adenohypophysis. Anat. Rec. 115, 390 (1953).
Green, J. D.: The comparative anatomy of the hypophysis, with special reference to its blood supply and innervation. Amer. J. Anat. 88, 225–312 (1951).
Green, J. D., and V. L. van Breemen: Electron microscopy of the pituitary and observations on neurosecretion. Amer. J. Anat. 97, 177–227 (1955).
Green, J. D., and G. W. Harris: The neurovascular link between the neurohypophysis and adenohypophysis. J. Endocr. 5, 136–146 (1947).
—: Observation of the hypophysis-portal vessels of living rat. J. Physiol. (Lond.) 108, 359–361 (1949).
Harris, G. W.: Electrical stimulation of the hypothalamus and the mechanism of neural control of the adenohypophysis. J. Physiol. (Lond.) 107, 418–429 (1948).
- Neural control of the pituitary gland. Brit. med. J. 1951 II, 559–627.
Hild, W.: Zur Frage der Neurosekretion im Zwischenhirn der Schleie (Tinca vulgaris) und ihrer Beziehungen zur Neurohypophyse. Z. Zellforsch. 35, 33–46 (1950).
—: Experimentell-morphologische Untersuchungen über das Verhalten der „Neurosekretorischen Bahn“ nach Hypophysenstieldurchtrennungen, Eingriffen in den Wasserhaushalt und Belastung der Osmoregulation. Virchows Arch. path. Anat. 319, 526–546 (1951).
—: Das Verhalten des neurosekretorischen Systems nach Hypophysenstieldurchschneidung und die physiologische Bedeutung des „Neurosekrets“. Acta neuroveg. (Wien) 3, 81–91 (1951).
Hild, W., u. G. Zetler: Über das Vorkommen der Hypophysenhinterlappenhormone im Zwischenhirn. Naunyn-Schmiedeberg's Arch. exp. Path. Pharmak. 213, 139–153 (1951).
Metuzals, J.: Über eigenartige Nervenzellen in der Hypophyse des Bitterlings (Rhodeus Amarus Bl.). Acta anat. (Basel) 14, 124–140 (1952).
—: Neurohistologische Studien über die nervöse Verbindung der Pars distalis der Hypophyse mit den Hypothalamus auf dem Wege des Hypophysenstieles. Acta anat. (Basel) 20, 258–285 (1954).
Moll, J.: Regeneration of the supraoptico-hypophyseal and paraventriculo-hypophyseal tracts in the hypophysectomized rat. Z. Zellforsch. 46, 686–709 (1957).
—: The effect of hypophysectomy on the pituitary vascular systems of the rat. J. Morph. 102, 1–21 (1958).
Palay, S. L.: Neurosecretory phenomena in the hypothalamo-hypophysial system of man and monkey. Amer. J. Anat. 93, 107–141 (1953).
Popa, G., and U. Fielding: A portal circulation from the pituitary to the hypothalamic region. J. Anat. (Lond.) 65, 88–91 (1930).
Scharrer, E.: Das Hypophysen-Zwischenhirnsystem der Wirbeltiere. Anat. Anz. (Erg.-Heft) 100, 5–29 (1954).
Scharrer, E., u. B. Scharrer: Neurosekretion. In Handbuch der mikroskopischen Anatomie des Menschen. Bd. VI, Teil 5, S. 953–1066. Berlin-Göttingen-Heidelberg: Springer 1954.
Sloper, J. C.: Hypothalamo-neurohypophysial neuroseeretion. Int. Rev. Cytol. 7, 337–389 (1958).
Spatz, H.: Neues über die Verknüpfung von Hypophyse und Hypothalamus. Mit besonderer Berücksichtigung der Regulation sexueller Leistungen. Acta neuroveg. (Wien) 3, 6–49 (1951).
—: Das Hypophysen-Hypothalamus-System in seiner Bedeutung für die Fortpflanzung. Anat. Anz. (Erg.-Heft) 100, 46–86 (1954).
—: Die Proximale (supraselläre) Hypophyse, ihre Beziehungen zum Diencephalon und ihre Regenerationspotenz. Pathophys. dienceph. p. 53–77, Wien: Springer 1958.
Stutinsky, F. S.: Recherches expérimentales sur le complexe hypothalamo-neurohypophysaire Arch. Anat. micr. Morph. exp. 46, 93–158 (1957).
—:Rapports du neurosécrétat hypothalamique avec l'adéno-hypophyse dans des conditions normales et expérimentales. Pathophys. dienceph. p. 78–103. Wien: Springer 1958.
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Dierickx, K., van den Abeele, A. On the relations between the hypothalamus and the anterior pituitary in Rana temporaria . Zeitschrift für Zellforschung 51, 78–87 (1959). https://doi.org/10.1007/BF00345080
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DOI: https://doi.org/10.1007/BF00345080