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Autoradiographic studies of human chromosomes

VI. Comparison of the end-of-S patterns in lymphocytes and amniotic epithelial cells

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Abstract

Certain differences in the location of chromosomal material completing DNA synthesis late in the S-period of the cell cycle were demonstrated when a comparison was made between human blood lymphocytes and epithelial cells derived from term amnion grown in vitro for short periods of time. The differences in the patterns of synthesis between these two differentiated diploid cells, each from the same species but of different embryonic origins (mesodermal vs. ectodermal), functions in vivo, and appearances and growth characteristics in vitro, may be reflections of distinctive patterns of condensed interphase chromatin, i.e. a characteristic distribution of heterochromatin, and possibly also of different cellular functions in the organisms.

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Authors and Affiliations

  1. The New York Blood Center, New York City

    James German & Dianne Aronian

Authors
  1. James German
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  2. Dianne Aronian
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Additional information

Supported by research grants from the U.S. Public Health Service (HD 04134) and the National Science Foundation (GB 6282). These data were presented at the Fourth Basel Colloquium on Mammalian Sex Chromosomes in Differentiation and Development, March, 1967.

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German, J., Aronian, D. Autoradiographic studies of human chromosomes. Chromosoma 35, 99–110 (1971). https://doi.org/10.1007/BF00344685

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  • DOI: https://doi.org/10.1007/BF00344685

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