Abstract
Oral colon transit scintigraphy using indium-111 diethylene-triamine-pentaacetic acid was performed in 41 healthy subjects (22 females, 19 males) to determine variability with age and sex and to define normal ranges. Repeat studies were performed in 10 females and 9 males to assess intra-subject variability. Females showed slightly but significantly slower colonic transit than men and slightly greater intra-subject variability. There was no correlation between age and colonic transit. The results have implications for the definition of normal ranges.
Résumé
Une scintigraphie du temps de transit colique par ingestion d'indium-acide 111 diethylène-triaminepentaacetique a été réalisée chez 41 sujets sains (22 femmes et 19 hommes) en vue de rechercher la variabilité avec l'âge et le sexe et de définir les écarts normaux. Des études répétées ont été réalisées chez 10 femmes et 9 hommes pour s'assurer de la variabilité chez un même sujet. Les femmes montraient un transit colique peu mais significativement plus lent que les hommes et une variabilité chez un même individu un peu plus grande. Il n'y avait pas de corrélation entre l'âge et le transit colique. Ces résultats ont une implication pour la définition des écarts normaux.
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References
Hinton J, Lennard-Jones J, Young A (1969) A new method of studying gut transit times using radio-opaque markers. Gut 10:842–847
Becker U, Elsborg L (1979) A new method for the determination of gastrointestinal transit times. Scand J Gastroenterol 14:355–359
Cummings JH, Wiggins HS (1976) Transit through the gut measured by analysis of a single stool. Gut 17:219–223
Wyman JB, Heaton KW, Manning AP, Wicks AB (1978) Variability of colonic function in healthy individuals. Gut 19:46–50
Arhan P, Devroede G, Jehannin BA, Lanza M, Faverdin C, Dornic C, Persoz B, Tetreault L, Perey B, Pellerin D (1981) Segmental colonic transit time. Dis Colon Rectum 24:625–629
Chaussade S, Khyrai A, Roche H, Garret M, Gaudric M, Couturier E, Guerre J (1989) Determination of total and segmented colonic transit time in constipated patients. Results in 91 patients with a new simplified method. Dig Dis Sci 34:1168–1172
Ducrotte P, Rodomanska B, Weber J, Guillard JF, Lerebours E, Hecketsweiler P, Galmiche JP, Colin R, Denis P (1986) Colonic transit time of radiopaque markers and rectoanal manometry in patients complaining of constipation. Dis Colon Rectum 29:630–634
Medcalf AM, Phillips SF, Zinsmeister AR, Macarthy RL, Beart RW, Wolff BG (1987) Simplified assessment of segmental colonic transit. Gastroenterology 92:40–47
Hardy JG, Perkins AC (1985) Validity of the geometric mean correction in the quantification of whole bowel transit. Nucl Med Commun 6:217–224
Krevsky B, Malmud LS, D'ercole F, Maurer AH, Fisher RS (1986) Colonic transit scintigraphy. A physiologic approach to the quantitative measurement of colonic transit in humans. Gastroenterology 91:1102–1112
Kamm MA, Lennard-Jones JE, Thompson DG, Sobrack R, Garvie MW, Granowski M (1988) Dynamic scanning defines a colonic defect in severe idiopathic constipation. Gut 29:1085–1092
Madsen JL, Jensen M (1989) Gastrointestinal transit of technetium-99m-labeled cellulose fiber and indium-111-labeled plastic particles. J Nucl Med 30:402–406
McLean RG, Smart RC, Gaston-Parry D, Barbagallo S, Baker J, Lyons NR, Bruck CE, King DW, Lubowski DZ, Talley NA (1990) Colon transit scintigraphy in health and constipation using I-131-cellulose. J Nucl Med 31:985–989
Smart RC, McLean RG, Gaston-Parry D, Barbagallo S, Bruck CE, King DW, Lubowski DZ, Talley NA (1991) Comparison of oral iodine-131-cellulose and indium-111-DTPA as tracers for colon transit scintigraphy: analysis by colon activity profiles. J Nucl Med 32:1668–1674
Stubbs JB, Valenzuela GA, Stubbs CC, Croft BY, Teates D, Plankey MW, McCallum RW (1991) A non-invasive scintigraphic assessment of the colonic transit of nondigestible solids in man. J Nucl Med 32:1375–1381
Thomforde GM, Proano M, Camilleri M, Phillips ST, Chapman NJ, Brown ML (1989) Development of a noninvasive test for colonic transit in man: in vivo and in vitro studies. J Nucl Med 30:764
Villaneuva-Meyer J, Bazzochi G, Reddy N, Snape W, Mena I (1989) Colonic scintigraphy in patients with chromic constipation. J Nucl Med 30:887
Kaufman PN, Richter JE, Chilton HM, Kerr RM, Cowan RC, Gelfand DW, Ott DJ (1990) Effects of liquid vs solid diet in colonic transit in humans. Evaluation by standard colonic transit scintigraphy. Gastroenterology 98:73–81
Cancer BE, Ercan MT, Kapucu LO, Tuncel SA, Bekdik CF, Erbengi GF, Piskin E (1991) Functional assessment of human gastrointestinal tract using 99 m Tc-latex particles. Nucl Med Commun 12:539–554
Van der Sijp JR, Kamm MA, Nightingale JM, Walker E, Granowska M, Morris GP, Lennard-Jones JE, Akkermanns LM (1991) Regional colonic transit: radioisotope resin demonstrates invalidity of plastic radioopaque markers in patients with severe idiopathic constipation. Gastroenterology 100:A503
Klein HA, Wald A (1985) Normal variation in radionuclide esophageal transit. J Nucl Med 26:P39
Roland J, Dobbeleir A, Vandevivere J, Ham HR (1990) Evaluation of reproducibility of solid-phase gastric emptying in healthy subjects. Eur J Nucl Med 17:130–133
Datz FL, Christian PE, Moore JA (1986) Sex-related differences in gastric emptying. J Nucl Med 27:904
Wald A, Van Thiel PH, Hoechstetter L, Galaver JS, Egler KM, Verm R, Scott L, Lester R (1981) Gastrointestinal transit: the effect of the menstrual cycle. Gastroenterology 80:1497–1500
Davies GJ, Crowder M, Reid B, Dickerson JW (1986) Bowel function measurements of individuals with different eating patterns. Gut 27:164–169
Turnball GK, Thompson DG, Day S, Martin J, Walker E, Lennard-Jones JE (1989) Relationships between symptoms, menstrual cycle and oro-caecal transit in normal and constipated women. Gut 30:30–34
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McLean, R.G., Smart, R.C., Lubowski, D.Z. et al. Oral colon transit scintigraphy using indium-111 DTPA: variability in healthy subjects. Int J Colorect Dis 7, 173–176 (1992). https://doi.org/10.1007/BF00341215
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DOI: https://doi.org/10.1007/BF00341215