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Radionuclide Gastrointestinal Transit Tests

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Pediatric Neurogastroenterology

Abstract

Scintigraphic techniques in the investigation of the gastrointestinal tract (GIT) have been in clinical use for decades but until recently have been little utilized in clinical practice. Scintigraphy is considered the gold standard for measuring gastric motility, but its clinical application has been limited in view of the lack of standardization of the technique. The large variety of the radiolabeled meals in use has made it difficult to define a normal range that is applicable to all centers, thus generating uncertainties in the value of the technique. The difficulty in recruiting pediatric normal volunteers to establish a normal range of the radionuclide gastric emptying study has added to the problem. Small bowel and colonic transit scintigraphic studies in children are performed only in selected specialized centers.

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References

  1. Rao SS, Camilleri M, Hasler WL, Maurer AH, Parkman HP, Saad R, et al. Evaluation of gastrointestinal transit in clinical practice: position paper of the American and European Neurogastroenterology and Motility Societies. Neurogastroenterol Motil. 2011;23(1):8–23.

    Article  CAS  PubMed  Google Scholar 

  2. Camilleri M, Hasler WL, Parkman HP, Quigley EM, Soffer E. Measurement of gastrointestinal motility in the GI laboratory. Gastroenterology. 1998;115(3):747–62.

    Article  CAS  PubMed  Google Scholar 

  3. Abell TL, Camilleri M, Donohoe K, Hasler WL, Lin HC, Maurer AH, et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American neurogastroenterology and motility society and the society of nuclear medicine. J Nucl Med Technol. 2008;36(1):44–54.

    Article  PubMed  Google Scholar 

  4. Abell TL, Camilleri M, Donohoe K, Hasler WL, Lin HC, Maurer AH, et al. Consensus recommendations for gastric emptying scintigraphy: a joint report of the American neurogastroenterology and motility society and the society of nuclear medicine. Am J Gastroenterol. 2008;103(3):753–63.

    Article  PubMed  Google Scholar 

  5. Maurer AH, Camilleri M, Donohoe K, Knight LC, Madsen JL, Mariani G, et al. The SNMMI and EANM practice guideline for small-bowel and colon transit 1.0. J Nucl Med. 2013;54(11):2004–13.

    Article  PubMed  Google Scholar 

  6. Odunsi ST, Camilleri M. Selected interventions in nuclear medicine: gastrointestinal motor functions. Semin Nucl Med. 2009;39(3):186–94.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Treves ST, Parisi MT, Gelfand MJ. Pediatric radiopharmaceutical doses: new guidelines. Radiology. 2011;261(2):347–9.

    Article  PubMed  Google Scholar 

  8. Gelfand MJ, Parisi MT, Treves ST. Pediatric radiopharmaceutical administered doses: 2010 North American consensus guidelines. J Nucl Med. 2011;52(2):318–22.

    Article  PubMed  Google Scholar 

  9. Kazem I. A new scintigraphic technique for the study of the esophagus. Am J Roentgenol Radium Therapy, Nucl Med. 1972;115(4):681–8.

    Article  CAS  Google Scholar 

  10. Mariani G, Boni G, Barreca M, Bellini M, Fattori B, AlSharif A, et al. Radionuclide gastroesophageal motor studies. J Nucl Med. 2004;45(6):1004–28.

    PubMed  Google Scholar 

  11. Tatsch K, Voderholzer WA, Weiss MJ, Schrottle W, Hahn K. Reappraisal of quantitative esophageal scintigraphy by optimizing results with ROC analyses. J Nucl Med. 1996;37(11):1799–805.

    CAS  PubMed  Google Scholar 

  12. Tatsch K, Schroettle W, Kirsch CM. Multiple swallow test for the quantitative and qualitative evaluation of esophageal motility disorders. J Nucl Med. 1991;32(7):1365–70.

    CAS  PubMed  Google Scholar 

  13. Warrington JC, Charron M. Pediatric gastrointestinal nuclear medicine. Semin Nucl Med. 2007;37(4):269–85.

    Article  PubMed  Google Scholar 

  14. Howarth D, Oldfield G, Booker J, Tan P. Esophageal dysfunction in patients with atypical chest pain investigated with esophageal scintigraphy and myocardial perfusion imaging: an outcome study. J Nucl Cardiol. 2003;10(5):490–7.

    Article  PubMed  Google Scholar 

  15. Stier AW, Stein HJ, Siewert JR, Schwaiger M. Image processing in esophageal scintigraphy: topography of transit times. Dis Esophagus. 2000;13(2):152–60.

    Article  CAS  PubMed  Google Scholar 

  16. Taillefer R, Jadliwalla M, Pellerin E, Lafontaine E, Duranceau A. Radionuclide esophageal transit study in detection of esophageal motor dysfunction: comparison with motility studies (manometry). J Nucl Med. 1990;31(12):1921–6.

    CAS  PubMed  Google Scholar 

  17. Geatti O, Shapiro B, Fig LM, Fossaluzza V, Franzon R, De Vita S, et al. Radiolabelled semisolid test meal clearance in the evaluation of esophageal involvement in scleroderma and Sjogren’s syndrome. Am J Physiol Imaging. 1991;6(2):65–73.

    CAS  PubMed  Google Scholar 

  18. Rudd TG, Christie DL. Demonstration of gastroesophageal reflux in children by radionuclide gastroesophagography. Radiology. 1979;131(2):483–6.

    Article  CAS  PubMed  Google Scholar 

  19. Heyman S. Gastric emptying in children. J Nucl Med. 1998;39(5):865–9.

    CAS  PubMed  Google Scholar 

  20. Vandenplas Y, Derde MP, Piepsz A. Evaluation of reflux episodes during simultaneous esophageal pH monitoring and gastroesophageal reflux scintigraphy in children. J Pediatr Gastroenterol Nutr. 1992;14(3):256–60.

    Article  CAS  PubMed  Google Scholar 

  21. Ravelli AM, Panarotto MB, Verdoni L, Consolati V, Bolognini S. Pulmonary aspiration shown by scintigraphy in gastroesophageal reflux-related respiratory disease. Chest. 2006;130(5):1520–6.

    Article  PubMed  Google Scholar 

  22. Reyhan M, Yapar AF, Aydin M, Sukan A. Gastroesophageal scintigraphy in children: a comparison of posterior and anterior imaging. Ann Nucl Med. 2005;19(1):17–21.

    Article  PubMed  Google Scholar 

  23. Blumenthal I, Lealman GT. Effect of posture on gastro-oesophageal reflux in the newborn. Arch Dis Child. 1982;57(7):555–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Maurer AH, Parkman HP. Update on gastrointestinal scintigraphy. Semin Nucl Med. 2006;36(2):110–18.

    Article  PubMed  Google Scholar 

  25. Arasu TS, Wyllie R, Fitzgerald JF, Franken EA, Siddiqui AR, Lehman GA, et al. Gastroesophageal reflux in infants and children comparative accuracy of diagnostic methods. J Pediatr. 1980;96(5):798–803.

    Article  CAS  PubMed  Google Scholar 

  26. Vandenplas Y, Rudolph CD, Di Lorenzo C, Hassall E, Liptak G, Mazur L, et al. Pediatric gastroesophageal reflux clinical practice guidelines: joint recommendations of the North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition (NASPGHAN) and the European Society for Pediatric Gastroenterology, Hepatology, and Nutrition (ESPGHAN). J Pediatr Gastroenterol Nutr. 2009;49(4):498–547.

    Article  PubMed  Google Scholar 

  27. Ziessman HA, Okolo PI, Mullin GE, Chander A. Liquid gastric emptying is often abnormal when solid emptying is normal. J Clin Gastroenterol. 2009;43(7):639–43.

    Article  PubMed  Google Scholar 

  28. Ziessman HA, Chander A, Clarke JO, Ramos A, Wahl RL. The added diagnostic value of liquid gastric emptying compared with solid emptying alone. J Nucl Med. 2009;50(5):726–31.

    Article  PubMed  Google Scholar 

  29. Camilleri M, Bharucha AE, Farrugia G. Epidemiology, mechanisms, and management of diabetic gastroparesis. Clin Gastroenterol Hepatol. 2011;9(1):5–12. quiz e7.

    Article  PubMed  Google Scholar 

  30. Donohoe KJ, Maurer AH, Ziessman HA, Urbain JL, Royal HD, Martin-Comin J. Procedure guideline for adult solid-meal gastric-emptying study 3.0. J Nucl Med Technol. 2009;37(3):196–200.

    Article  PubMed  Google Scholar 

  31. Drubach LA, Kourmouzi V, Fahey FH. Cheese is a reliable alternative meal for solid-phase gastric emptying study. Nucl Med Commun. 2010;31(5):430–3.

    PubMed  Google Scholar 

  32. Singh SJ, Gibbons NJ, Blackshaw PE, Vincent M, Wakefield J, Perkins AC. Gastric emptying of solids in normal children—a preliminary report. J Pediatr Surg. 2006;41(2):413–17.

    Article  PubMed  Google Scholar 

  33. Somasundaram VH, Subramanyam P, Palaniswamy SS. A gluten-free vegan meal for gastric emptying scintigraphy: establishment of reference values and its utilization in the evaluation of diabetic gastroparesis. Clin Nucl Med. 2014;39(11):960–5.

    Article  PubMed  Google Scholar 

  34. Southwell BR, Clarke MC, Sutcliffe J, Hutson JM. Colonic transit studies: normal values for adults and children with comparison of radiological and scintigraphic methods. Pediatr Surg Int. 2009;25(7):559–72.

    Article  PubMed  Google Scholar 

  35. Argenyi EE, Soffer EE, Madsen MT, Berbaum KS, Walkner WO. Scintigraphic evaluation of small bowel transit in healthy subjects: inter- and intrasubject variability. Am J Gastroenterol. 1995;90(6):938–42.

    CAS  PubMed  Google Scholar 

  36. Charles F, Camilleri M, Phillips SF, Thomforde GM, Forstrom LA. Scintigraphy of the whole gut: clinical evaluation of transit disorders. Mayo Clin Proc. 1995;70(2):113–18.

    Article  CAS  PubMed  Google Scholar 

  37. Cremonini F, Mullan BP, Camilleri M, Burton DD, Rank MR. Performance characteristics of scintigraphic transit measurements for studies of experimental therapies. Aliment Pharmacol Ther. 2002;16(10):1781–90.

    Article  CAS  PubMed  Google Scholar 

  38. Cook BJ, Lim E, Cook D, Hughes J, Chow CW, Stanton MP, et al. Radionuclear transit to assess sites of delay in large bowel transit in children with chronic idiopathic constipation. J Pediatr Surg. 2005;40(3):478–83.

    Article  PubMed  Google Scholar 

  39. Chitkara DK, Bredenoord AJ, Cremonini F, Delgado-Aros S, Smoot RL, El-Youssef M, et al. The role of pelvic floor dysfunction and slow colonic transit in adolescents with refractory constipation. Am J Gastroenterol. 2004;99(8):1579–84.

    Article  PubMed  Google Scholar 

  40. Camilleri M. Scintigraphic biomarkers for colonic dysmotility. Clin Pharmacol Ther. 2010;87(6):748–53.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Osvaldo Borrelli M.D., Ph.D. .

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Biassoni, L., Easty, M., Borrelli, O. (2017). Radionuclide Gastrointestinal Transit Tests. In: Faure, C., Thapar, N., Di Lorenzo, C. (eds) Pediatric Neurogastroenterology. Springer, Cham. https://doi.org/10.1007/978-3-319-43268-7_14

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  • DOI: https://doi.org/10.1007/978-3-319-43268-7_14

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