Summary
Intercellular adhesion molecule-1 (ICAM-1) was localized immunohistochemically in postmortem brain tissue of Alzheimer's disease (AD), progressive supranuclear palsy, amyotrophic lateral sclerosis, Pick's disease, and controls. In controls, only capillaries were stained for ICAM-1. In affected areas of neurologically disease brains, a subset of reactive astrocytes was also strongly stained. In addition, there were irregular, diffuse patches of positive staining in the tissue matrix. In AD, many of these patches had dense cores which corresponded with senile plaques. Double immunostaining for glial fibrillary acidic protein and ICAM-1 indicated that some reactive astrocytes at the periphery of senile plaques were positive for ICAM-1. Within such plaques, microglial aggregates were stained intensely for leukocyte function-associated antigen-1 (LFA-1), the adhesion molecule for ICAM-1. The LFA-1/ICAM-1 system appears to play an important role in the interaction of astrocytes and microglia in several neurological diseases.
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References
Akiyama H, McGeer PL (1990) Brain microglia constitutively express β2 integrins. J Neuroimmunol 30:81–93
Altieri DC (1991) Occupancy of CD11b/CD18 (Mac-1) divalent ion binding site(s) induces leukocyte adhesion. J Immunol 147:1891–1898
Dunn SM, Hillam AJ, Stomski F, Jin BQ, Lucas CM, Boyd AW, Krissansen GW, Burns GF (1989) Leukocyte adhesion molecules involved in inflammation. Transplant Proc 21:31–34
Figdor CG, van Kooyk Y, Keizer GD (1990) On the mode of action of LFA-1. Immunol Today 11:277–280
Frohman EM, Frohman TC, Dustin ML, Vayuvegula B, Choi B, Gupta A, van den Noort S, Gupta S (1989) Induction of intercellular adhesion molecule 1 (ICAM-1) expression on human fetal astrocytes by interferon-gamma, tumor necrosis factor-alpha, lymphotoxin and interleukin-1: relevance to intracerebral antigen presentation. J Neuroimmunol 23:117–124
Frohman EM, Frohman TC, Gupta S, de Fougerolles A, van den Noort S (1991) Expression of intercellular adhesion molecule 1 (ICAM-1) in Alzheimer's disease. J Neurol Sci 106:105–111
Hildreth JEK, Gotch FM, Hildreth PD, McMichael AJ (1983) A human lymphocyte-associated antigen involved in cell-mediated lympholysis. Eur J Immunol 13:202–208
Kametani F, Tanaka K, Haga S, Satoh M, Allsop D, Ishii T (1989) Demonstration of a 72K beta-protein precursor fragment in Alzheimer and normal aged brain. Biomed Res 10:179–183
Kawamata T, Akiyama H, Yamada T, McGeer PL (1992) Immunological reactions in amyotrophic lateral slcerosis brain and spinal cord tissue. Am J Pathol 140:691–707
Kishimoto TK, Larson RS, Corbi AL, Dustin ML, Staunton DE, Springer TA (1988) Leukocyte integrins. In: Springer TA, Anderson DC, Rosental AS, Rothlein R (eds) Leukocyte adhesion molecules. Springer-Verlag, New York, Berlin Heidelberg pp 7–43
Makgoba MW, Sanders ME, Ginther Luce GE, Springer TA, Shaw S (1988) ICAM-1 a ligand for LFA-1 dependent adhesion of B, T and myeloid cells. Nature 331:86–88
McGeer PL, Akiyama H, Itagaki S, McGeer EG (1989) Immune system response in Alzheimer's disease. Can J Neurol Sci 16:516–527
McGeer PL, Akiyama H, Itagaki S, McGeer EG (1989) Activation of the classical complement pathway in brain tissue of Alzheimer patients. Neurosci Lett 107:341–346
McGeer PL, Akiyama H, Kawamata T (1991) Integrin expression in Alzheimer brain tissue. In: Iqbal K, McLachlan DRC, Windblad B, Wisniewski HM (eds) Alzheimer's disease: basic mechanism, diagnosis and therapeutic strategy. Wiley & Sons, New York, pp 587–601
O'Neill JK, Butter C, Baker D, Gschmeissner SE, Kraal G, Butcher EC, Turk JL (1991) Expression of vascular addressins and ICAM-1 by endothelial cells in the spinal cord during chronic relapsing experimental allergic encephalomyelitis in the Biozzi AB/H mouse. Immunology 72:520–525
Osborn L (1990) Leukocyte adhesion to endothelium in inflammation. Cell 62:3–6
Patarroyo M, Prieto J, Beatty PG, Clark E, Gahmberg CG (1988) Adhesion-mediating molecules of human monocytes. Cell Immunol 113:278–289
Patarroyo M, Prieto J, Rincon J, Timonen T, Lundberg C, Lindbom L, Asjoe B, Gahmberg CG (1990) Leukocyte-cell adhesion: a molecular process fundamental in leukocyte physiology. Immunol Rev 114:67–108
Raine CS, Cannella B, Duijvestijn AM, Cross AH (1990) Homing to central nervous system vasculature by antigen-specific lymphocytes. II. Lymphocyte/endothelial cell adhesion during the initial stages of autoimmune demyelination. Lab Invest 63:476–489
Rössler K, Neuchrist C, Kitz K, Scheiner O, Kraft D, Lassmann H (1992) Expression of leucocyte adhesion molecules at the human blood-brain barrier (BBB). J Neurosci Res 31:365–374
Rothlein R, Dustin ML, Marlin SD, Springer TA (1986) A human intercellular adhesion molecule (ICAM-1) distinct from LFA-1. J Immunol 137:1270–1274
Rozemuller JM, Eikelenboom P, Pals ST, Stam FC (1989) Microglial cells around amyloid plaques in Alzheimer's disease express leucocyte adhesion molecules of the LFA-1 family. Neurosci Lett 101:288–292
Satoh J, Kim SU, Kastrukoff LF, Takei F (1991) Expression and induction of intercellular adhesion molecules (ICAMs) and major histocompatibility complex (MHC) antigens on cultured murine oligodendrocytes and astrocytes. J Neurosci Res 29:1–12
Schwarting R, Stein H, Wang CY (1985) The monoclonal antibodies αS-HCL 1 (αLeu-14) and αS-HCL 3 (αLeu M5) allow the diagnosis of hairy cell leukemia. Blood 65:974–983
Seth R, Raymond FD, Makgoba MW (1991) Circulating ICAM-1 isoforms: diagnostic prospects for inflammatory and immune disorders. Lancet 338:83–84
Sobel RA, Mitchell ME, Fondren G (1990) Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol 136:1309–1316
Springer TA, Lasky LA (1991) Sticky sugars for selectins. Nature 349:196–197
Stoolman LM (1989) Adhesion molecules controlling lymphocyte migration. Cell 56:907–910
Todd RF, Van Agthoven A, Schlossman SF, Terhorst C (1982) Structural analysis of differentiation antigens Mo1 and Mo2 on human monocytes. Hybridoma 1:329–337
Wilcox CE, Ward AMV, Evans A, Baker D, Rothlein R, Turk JL (1990) Endothelial cell expression of the intercellular adhesion molecule-1 (ICAM-1) in the central nervous system of guinea pigs during acute and chronic relapsing experimental allergic encephalomyelitis. J Neuroimmunol 30:43–51
Yamada T, Akiyama H, McGeer PL (1990) Complement-activated oligodendroglia: a new pathogenic entity identified by immunostaining with antibodies to human complement proteins C3d and C4d. Neurosci Lett 112:161–166
y Cajal SR (1984) Neuroglia. In: de la Torre J, Gibson WC (eds and translators) The neuron and the glial cell. Thomas, Springfield, pp 263–290
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Supported by grants from the Foundation for Total Health Promotion (HA), the Sasakawa Research Foundation (HA), the Alzheimer Society of B.C. and the MRC of Canada, as well as donations from individual British Columbians
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Akiyama, H., Kawamata, T., Yamada, T. et al. Expression of intercellular adhesion molecule (ICAM)-1 by a subset of astrocytes in Alzheimer disease and some other degenerative neurological disorders. Acta Neuropathol 85, 628–634 (1993). https://doi.org/10.1007/BF00334673
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DOI: https://doi.org/10.1007/BF00334673