Abstract
Corn-cob was used as a substrate in the production of oxytetracycline by Streptomyces rimosus TM-55 in a solidstate fermentation. Oxytetracycline was detected on day 4, and reached its maximum on day 8. Optimal conditions for oxytetracycline production were an initial pH of 5.2 to 6.3, an initial moisture content of 64% to 67%, supplementation with 20% (w/w) rice bran or 1.5% to 2.5% (w/w) (NH4)2SO4 as sole N source, 1.0% (w/w) CaCO3, 2% (w/w) MgSO4.7H2O, and 0.5% (w/w) KH2PO4, with incubation for 8 days at 25 to 30°C. Each g substrate produced 7 to 8 mg oxytetracycline.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Ahmed, L., Germain, P. & Lefebrve, G. 1987 Phosphate repression of cephamycin and clavulanic acid production by Streptomyces clavuligerus. Applied Microbiology and Biotechnology 26, 130–135.
Bhatnagar, R.K., Doull, J.L. & Vining, L.C. 1988 Role of the carbon source in regulating chloramphenicol production by Streptomyces venezulae: studies in batch and continuous cultures. Canadian Journal of Microbiology 34, 1217–1233.
Huang, J.H. 1972 Antibiotics, pp. 234–268. Taipei: Tafu.
Komatsu, K.I., Mizuno, M. & Kodaira, R. 1975 Effect of methionines on cephalosporin C and penicillin N production by a mutant of Cephalosporium acremonium. Journal of Antibiotics 28, 881–888.
Shen, Y.Q., Heim, J., Solomon, N.A., Wolfe, S. & Demain, A.L. 1984 Repression of beta-lactam production in Cephalosporium acremonium by nitrogen sources. Journal of Antibiotics 37, 503–511.
Somerson, N.L. & Phillips, T. 1961 Production of glutamic acid. U.S. Patent 3,080,297, 37-1, 695.
Treskatis, D.H., King, R., Wolf, H. & Gilles, E.D. 1992. Nutritional control of nikkomycin and juglomycin production by Streptomyces tendae in continuous culture. Applied Microbiology and Biotechnology 36, 440–445.
Wang, H.H. 1989 Utilization of particulate agricultural products through solid state fermentation. Proceedings of the National Science Council, Republic of China, Part B, 13, 145–159.
Yang, S.S. 1977 Quantitative determination of soil gas with regard to soil microbial activities. National Science Council Monthly 5, 478–502.
Yang, S.S. 1993 Protein enrichment of sweet potato residue with co-culture of amylolytic fungi by solid-state fermentation. Biotechnology Advances 11, 495–505.
Yang, S.S. & Cheng, Z.J. 1991 Protein enrichment of corn-cob with Trichoderma by solid-state fermentation. Chinese Journal of Microbiology and Immunology 24, 177–195.
Yang, S.S. & Huang, C.I. 1994 Protease production by amylolytic fungi in solid-state fermentation. Journal of the Chinese Agricultural Chemical Society 32, 589–601.
Yang, S.S. & Ling, M.Y. 1989 Tetracycline production with sweet potato residue by solid-state fermentation. Biotechnology and Bioengineering 33, 1021–1028.
Yang, S.S. & Yuan, S.S. 1990 Oxytetracycline production by Streptomyces rimosus in solid-state fermentation of sweet potato residue. World Journal of Microbiology and Biotechnology 6, 236–244.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Yang, S.S., Swei, W.J. Oxytetracycline production by Streptomyces rimosus in solid-state fermentation of corncob. World J Microbiol Biotechnol 12, 43–46 (1996). https://doi.org/10.1007/BF00327798
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00327798