Abstract
A model is presented, which is based on the idea that the chromosome damage induced by Mitomycin C results directly from repair or misrepair of DNA molecules responsible for the linear continuity of the chromosomes. Testing the model with human cells confirms the prediction that exchanges with complete joining occur between chromosome regions containing homologous, repetitive DNA. Most probably incomplete exchanges involve homologous, but unique DNA sequences. — Prerequisites determining the MC-induced aberration patterns are the distribution of the chemical due to compartmentalization, the somatic pairing of chromosomes, and the occurrence of repeated or unique DNA sequences. — The scoring of different classes of MC-induced chromatid aberrations (attenuation, constriction, gap, break) in alcohol/acetic acid-fixed chromosome has a limited value.
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Brøgger, A., Johansen, J. A model for the production of chromosome damage by Mitomycin C. Chromosoma 38, 95–104 (1972). https://doi.org/10.1007/BF00319957
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DOI: https://doi.org/10.1007/BF00319957