Abstract
A method is presented that allows the measurement of erythrocyte filtration times that are extremely prolonged. Filtration times through polycarbonate sieves are increased by a factor of 40 after 2 h incubation with 30 mM sodium chlorate. This increase in red cell rigidity offers an explanation for the haemolysis observed in chlorate poisoning in vivo.
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References
Braasch D (1971) Deformability and traversing time of shape-transformed single red cells passing through a 4 μm glass capillary. Pflügers Arch 329: 167–171
Gordon S, Brown JAH (1974) Potassium chlorate poisoning. Lancet 2: 503–504
Klendshoj NC, Burke WJ, Anthone R, Anthone S (1962) Chlorate poisoning. J Am Med Assoc 180: 1133–1135
Marchand F (1887) Über die giftige Wirkung der chlorsauren Salze. Naunyn-Schmiedebergs Arch Exp Pathol Pharmakol 22: 201–233
Reid HL, Barnes AJ, Lock PJ, Dormandy JA, Dormandy TL (1976) A simple method for measuring erythrocyte deformability. J Clin Pathol 29: 855–858
Roggenkamp HG, Kiesewetter H, Schmeink T, Hollweg HG (1982) Ein neues Verfahren zur Quantifizierung der Verformbarkeit von Erythrocyten. Biomed Technik 27: 162–166
Schmidt-Schönbein H, Weiss H, Ludwig H (1973) A simple method for measuring red cell deformability in models of the microcirculation. Blut 26: 369–379
Steffen C, Seitz R (1981) Severe chlorate poisoning: report of a case. Arch Toxicol 48: 281–288
Zijlstra WG (1956) Die quantitative Bestimmung von Hämoglobin, Oxyhämoglobin, Kohlenoxydhämoglobin und Methämoglobin in kleinen Blutproben. Klin Wochenschr 34: 384–388
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Steffen, C., Singelmann, E. Improved method to measure erythrocyte filtration times increased extremely by chlorate. Arch Toxicol 53, 249–252 (1983). https://doi.org/10.1007/BF00316509
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DOI: https://doi.org/10.1007/BF00316509